Epileptogenesis in neonatal brain

Seminars in Fetal & Neonatal Medicine
Anna-Maria KatsarouSolomon L Moshé

Abstract

Epilepsy is a chronic neurological disorder affecting 65 million people worldwide. The etiologies of seizures can often be identified as genetic, metabolic, structural, immunologic or infectious, but in many cases the cause is unknown with the current diagnostic tools. Epileptogenesis is a process during which genetic or other acquired etiologies/insults lead to functional, structural, or network reorganization changes in the brain that may lead to the development of, or progression of, spontaneous seizures. During development, there are continuous changes in the structure, function, and network operation that also show sex specificity, which may alter the mechanisms underlying the generation of seizures (ictogenesis) and epileptogenesis. Understanding the mechanisms of early life epileptogenesis will enable the development of rationally designed age- and sex-appropriate therapies that would improve the overall quality of patients' lives. Here, we discuss some of these processes that may affect seizure generation and epileptogenesis in the neonatal brain.

References

Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Mar 1, 1984·Brain Research·B J AlbalaR Okada
May 1, 1982·Brain Research·S L Moshé, B J Albala
Mar 17, 2006·Neuroscience Letters·Andreas KyrozisAristea S Galanopoulou
Oct 24, 2007·The Journal of Comparative Neurology·Shilpa D Kadam, F Edward Dudek
Feb 15, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aristea S Galanopoulou
Mar 14, 2008·Epilepsy & Behavior : E&B·Henry HassonSolomon L Moshé
Jun 6, 2008·Epilepsy Research·Aristea S Galanopoulou
Oct 1, 2008·Annals of Neurology·Cindy ChiuSteven Petrou
Oct 7, 2008·Progress in Neurobiology·Roland A Bender, Tallie Z Baram
Jul 7, 2009·Nature Reviews. Neurology·Sanjay N Rakhade, Frances E Jensen
Dec 1, 2009·Neurobiology of Disease·Morris H ScantleburySolomon L Moshé
Jan 8, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shilpa D KadamF Edward Dudek
Mar 17, 2010·Epilepsy Currents·Chrysanthy Ikonomidou
Mar 31, 2010·Pflügers Archiv : European journal of physiology·Aristea S Galanopoulou
Apr 5, 2011·Epilepsy Currents·Tallie Z BaramAmy Brooks-Kayal
Apr 21, 2011·Neurobiology of Disease·Emmanuel RaffoAristea S Galanopoulou
Jun 23, 2011·European Journal of Human Genetics : EJHG·Alex R PaciorkowskiWilliam B Dobyns
Aug 10, 2011·Neural Plasticity·Stephen W Briggs, Aristea S Galanopoulou
Oct 19, 2011·Biomarkers in Medicine·Aristea S Galanopoulou, Solomon L Moshé
Jan 15, 2013·Brain & Development·Aristea S Galanopoulou
Aug 9, 2013·Epilepsia·Asla PitkänenDieter Schmidt
Aug 13, 2013·Nature·Andrew S AllenMelodie R Winawer
Feb 5, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Asla Pitkänen, Jerome Engel
Apr 16, 2014·Epilepsia·Robert S FisherSamuel Wiebe
May 24, 2014·Neurobiology of Disease·Fillippo Sean GiorgiSolomon L Moshé
May 31, 2014·Neurobiology of Disease·Ozlem AkmanAristea S Galanopoulou
Jul 24, 2014·Epilepsia·Nicholas M AllenMary D King
Sep 10, 2014·Progress in Brain Research·Ortrud K Steinlein
Sep 30, 2014·American Journal of Human Genetics·UNKNOWN EuroEPINOMICS-RES ConsortiumUNKNOWN Epi4K Consortium
Aug 15, 2015·Journal of Child Neurology·Semra Gürsoy, Derya Erçal
May 31, 2017·Annals of Neurology·Daniel ToroliraJerome Niquet
Jul 25, 2017·Neurology·Renée A ShellhaasUNKNOWN Neonatal Seizure Registry
Oct 25, 2017·Epilepsia Open·Anna-Maria KatsarouAristea S Galanopoulou

❮ Previous
Next ❯

Citations

Feb 23, 2020·Clinical Pediatrics·Meggan MurphyDaliah Wachs
Jan 9, 2021·Seizure : the Journal of the British Epilepsy Association·Francesco PisaniGeorgia Ramantani
Sep 6, 2020·Epilepsy & Behavior : E&B·Francesco PisaniCarlotta Spagnoli
Nov 22, 2019·Neuropharmacology·Ronit M Pressler, Lieven Lagae
Apr 9, 2021·Italian Journal of Pediatrics·Raffaele FalsaperlaMartino Ruggieri
Mar 19, 2019·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Joel FlussStéphane Chabrier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cellular Immunometabolism

Immunometabolism involves not only the way metabolites are digested by the immune system, but the way in which they can alter the pathway of the immune system. These responses occur in day-to-day healthy cell functioning, but can result in diseases, such as autoimmune disorders. Discover the latest research on cellular immunometabolism here.

Related Papers

Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics
Sandy R ShultzRuben I Kuzniecky
Annual Review of Pharmacology and Toxicology
Nicholas H VarvelRaymond Dingledine
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Clement HuneauFabrice Wendling
Neuroscience
Daniele BertoglioOlli Gröhn
© 2022 Meta ULC. All rights reserved