Epileptogenesis-induced changes of hippocampal-piriform connectivity.

Seizure : the Journal of the British Epilepsy Association
Mark D SkopinMohamad Z Koubeissi

Abstract

Tissue remodeling has been described in brain circuits that are involved in the generation and propagation of epileptic seizures. Human and animal studies suggest that the anterior piriform cortex (aPC) is crucial for seizure expression in focal epilepsies. Here, we investigate the effect of kainic-acid (KA)-induced seizures on the effective connectivity of the aPC with bilateral hippocampal CA3 regions using cerebro-cerebral evoked potentials (CCEPs). Adult male Sprague-Dawley rats were implanted with a tripolar electrode in the left aPC for stimulation and recording, and with unipolar recording electrodes in bilateral CA3 regions. Single pulse stimulations were given to the aPC and CCEPs were averaged before KA injections and after the emergence of spontaneous recurrent seizures (SRS). Similar recordings at equivalent time intervals were obtained from animals that received saline injections instead of KA (controls). In the experimental group, the percentage change of increased amplitude of the contralateral (but not ipsilateral) CA3 CCEPs between pre-KA injection and after the emergence of SRS was significantly greater than in controls. No significant single-pulse-induced spectral change responses were observed in either epil...Continue Reading

References

Aug 1, 1986·Archives of Neurology·G H WeissB Jabbari
Mar 1, 1974·Epilepsia·M E ScheibelA B Scheibel
Jul 1, 1980·Neurology·J F AnnegersL T Kurland
Feb 1, 1995·Italian Journal of Neurological Sciences·K Gale
Dec 1, 1996·Progress in Neurobiology·W Löscher, U Ebert
Oct 7, 1998·Epilepsy Research·C DeransartA Depaulis
Jun 4, 1999·Brain : a Journal of Neurology·J G Jefferys
Nov 13, 2002·Neurology·Susan T Herman
Aug 15, 2003·Journal of Neurophysiology·Kevin R Neville, Lewis B Haberly
Dec 20, 2005·Brain Research·Adnan H Siddiqui, Shirley A Joseph
Dec 22, 2007·Toxicologic Pathology·Alok K SharmaPaul W Snyder
Mar 25, 2011·Medical Hypotheses·Min FangXue-Feng Wang
Sep 16, 2011·Neurology·Martha J Morrell, UNKNOWN RNS System in Epilepsy Study Group
Oct 13, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Rei EnatsuDileep R Nair
Apr 19, 2013·Nature Reviews. Neuroscience·Ethan M Goldberg, Douglas A Coulter
Aug 19, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Rei EnatsuDileep R Nair
Feb 14, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·F ValloneA Di Garbo
Mar 15, 2015·Journal of Neuroscience Methods·Maxime LévesqueChristophe Bernard
Jun 16, 2015·Frontiers in Neural Circuits·Marta S VismerMohamad Z Koubeissi
Jan 23, 2017·Epilepsy & Behavior : E&B·Phillip ConnellMohamad Z Koubeissi
Jul 20, 2019·Experimental Neurology·Marco de CurtisMassimo Avoli
Jul 20, 2019·Experimental Neurology·James C YoungGraeme D Jackson
Dec 4, 2019·Experimental Neurology·Heming ChengZhong Chen
Apr 13, 2020·Experimental Neurology·Matthias Koepp, Marian Galovic
Apr 13, 2020·Experimental Neurology·Gregory LaneChristina Zelano

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Citations

Mar 1, 2021·Progress in Neurobiology·Guangyu ZhouChristina Zelano
May 1, 2021·Epilepsy Currents·Timothy DenisonCatherine Schevon

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