Epileptogenic properties of folic acid and N5 methyltetrahydrofolate in cat.

Epilepsia
F MauguiereS Bello

Abstract

The epileptogenic properties of folic acid and N5-methyltetrahydrofolate applied locally on the cortex were compared in cats. Neither substance was epileptogenic except in very high concentration, on the order of 10(-3) M. N5-Methyltetrahydrofolate, the folate derivative most widely distributed in the central nervous system and CSF of mammals, was not more epileptogenic than folic acid. Because the level of N5-methyltetrahydrofolate is only slightly diminished in patients treated with anticonvulsants, the change cannot account for the therapeutic effect of the drugs.

References

Oct 1, 1973·Journal of the Neurological Sciences·E A Obbens, O R Hommes
Jul 1, 1972·Journal of the Neurological Sciences·O R Hommes, E A Obbens
Dec 20, 1972·Nature: New Biology·R G Spector
Nov 17, 1972·Nature·E H ReynoldsA L Johnson
Aug 1, 1973·Archives of Neurology·R H MattsonD Glass
Jan 1, 1973·Archives of Neurology·D B Smith, L C Racusen
May 1, 1973·Journal of the Neurological Sciences·O R HommesC C Wijffels
Nov 1, 1973·Journal of the Neurological Sciences·O R Hommes, E A Obbens
Jul 1, 1971·Biochemical Pharmacology·R G Spector
Jun 27, 1970·British Medical Journal·C Neubauer
Jun 1, 1971·Clinical Science·H Carlisle, R G Spector
Jun 1, 1968·Brain : a Journal of Neurology·E H Reynolds
Aug 1, 1969·Archives of Neurology·O N Jensen, O V Olesen
Aug 1, 1967·The British Journal of Psychiatry : the Journal of Mental Science·E H Reynolds

❮ Previous
Next ❯

Citations

Jan 1, 1982·Journal of Neural Transmission·J M LootsM J Brennan
Mar 1, 1989·Epilepsia·H O GoodmanK S Oles
May 1, 1995·American Journal of Public Health·P S RomanoR D Pi
Aug 22, 2001·Obstetrics and Gynecology Clinics of North America·E R Pschirrer, M Monga
Jun 18, 2004·Obstetrics and Gynecology Clinics of North America·E Rebecca Pschirrer
Aug 1, 1979·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J Bruni, L J Willmore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved