Jun 2, 2016

Epimerization of Alanyl-Alanine Induced by γ-Rays Irradiation in Aqueous Solutions

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
Toratane Munegumi


Living organisms have homochiral L-amino acids in proteins and homochiral D-mononucleotides in nucleic acids. The chemical evolutionary process to protein homochirality has been discussed for many years. Although many scenarios have been proposed for homochirality in the monomeric compounds, homochirality in amino acids and mononucleotides does not always guarantee homochirality in polypeptides and polynucleotides. Integrated scenarios containing the pathways from monomer to polymer should be proposed because in the pathways oligomers and polymers as well as monomers racemize (or epimerize), degrade, and condense. This research addresses epimerization and degradation of dipeptides under γ-rays irradiation by a cobalt-60 ((60)Co) radiation source. The different rate constants of epimerization between diastereomeric dipeptides in the research suggest that the potential pathway toward homochirality could be much more complex.

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Mentioned in this Paper

Molecular Stereochemistry
Biochemical Pathway
Alanylalanine, (L-Ala)-(DL-Ala)-isomer
Amino Acids, I.V. solution additive
Flavin Mononucleotide
Evolution, Chemical
Cobalt Radioisotopes

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