PMID: 6107816Nov 1, 1980Paper

Epinephrine and norepinephrine are cleared through beta-adrenergic, but not alpha-adrenergic, mechanisms in man

Metabolism: Clinical and Experimental
P CryerJ Gerich

Abstract

Although catecholamines are rapidly removed from the extracellular fluid, the role of adrenergic mechanisms in the clearance of epinephrine and norepinephrine has not been defined. In five normal human subjects, mean (+/- SE) plasma epinephrine concentrations did not change during control infusions, rose from 21 +/- 6 pg/ml to 834 +/- 84 pg/ml during the infusion of epinephrine (50 ng/kg/min) over 180 min and to 853 +/- 112 pg/ml during the infusion of epinephrine plus phentolamine (500 micrograms/min after a 5.0 mg loading dose infused over 2 min), but to 2400 +/- 104 pg/ml during the infusion of epinephrine plus propranolol (80 micrograms/min after a 5.0 mg loading dose infused over 2 min), indicating that beta-adrenergic blockade sharply reduces the clearance of epinephrine in man. In separate studies in seven subjects, similar increments in plasma epinephrine occurred during the infusion of epinephrine alone and the clearance of epinephrine was comparably reduced during the infusion of epinephrine plus propranolol and during the infusion of epinephrine plus propranolol plus phentolamine, suggesting that the reduction of epinephrine clearance produced by beta-adrenergic blockade during epinephrine infusion is not mediated by...Continue Reading

References

Sep 1, 1978·Clinical Pharmacology and Therapeutics·D A RichardsR J Dobbs
Jun 1, 1978·European Journal of Clinical Investigation·K H RahnW Stephany
Feb 15, 1977·Biochemical Pharmacology·K StarkeE Browski
Dec 1, 1977·Acta Physiologica Scandinavica·H GalboJ J Holst
Feb 1, 1979·British Journal of Clinical Pharmacology·P J LijnenA F De Schaepdryver
Jun 1, 1976·Journal of Applied Physiology·H GalboJ Hilsted
May 27, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·O Almgren, J Jonason
Mar 1, 1980·The Journal of Clinical Investigation·R A RizzaJ E Gerich

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Citations

Feb 1, 1991·Clinical Endocrinology·A J KrentzM Nattrass
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·R D GordonB T Gueizelar
Jan 1, 1983·World Journal of Surgery·D S Gann, M P Lilly
Sep 8, 2001·American Journal of Physiology. Cell Physiology·R L StarkieM A Febbraio
Jan 29, 2011·Diabetes·Ranjani Ramanathan, Philip E Cryer
Jan 1, 1989·Clinical and Experimental Hypertension. Part A, Theory and Practice·P C ChangP van Brummelen
Apr 1, 1987·Clinical and Experimental Pharmacology & Physiology·G EisenhoferI J Kopin
Sep 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·E MaignanJ L Cuche
Jun 1, 1997·Journal of Applied Physiology·R S MazzeoM Esler
Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Shohei TakedaTeruaki Tomaru
Mar 1, 1987·Clinical and Experimental Pharmacology & Physiology·R D GordonY Dai
May 25, 1999·The Journal of Trauma·F A LuchetteJ H James
May 1, 1982·British Journal of Clinical Pharmacology·H H VincentM A Schalekamp
Sep 27, 2016·Diabetes/metabolism Research and Reviews·Wai Gin LeeLindsay D Plank
Jul 18, 2002·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·S SnitkerA Astrup
Jan 1, 1985·European Journal of Clinical Pharmacology·A D Struthers, C T Dollery
Jul 1, 1996·The American Journal of Physiology·C A ChuA D Cherrington
Mar 1, 1987·The American Journal of Physiology·S G RosenA J Zweifler
Apr 1, 1984·The American Journal of Physiology·S M PalmerD A Fisher
May 1, 1991·The American Journal of Physiology·J C MarkerP E Cryer
Jun 1, 1982·The Journal of Investigative Dermatology·H CrespiC Perec

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