Jun 1, 1976

Epinephrine-induced hepatic potassium movements before and after adrenergic blockade

Canadian Journal of Physiology and Pharmacology
S D Guthrie, Q R Murphy


The epinephrine-induced loss and subsequent uptake of K+ by the liver was studied by measuring hepatic arterio-venous K+ differences and splanchnic blood flows in anesthetized dogs with chronically implanted portal vein catheters and celiac and superior mesenteric artery flow probes. When epinephrine was administered intraportally, neither alpha- nor beta-adrenergic blockade, singly or in combination, had significant effects upon the hyperkalemic or the hypokalemic phases in either hepatic venous or systemic arterial blood. It was concluded that the movements of K+ into and out of the liver caused by epinephrine are not mediated by the classical adrenergic receptors as defined by inhibition by specific blocking agents.

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Mentioned in this Paper

Acute-Phase Reaction
Superior Mesenteric Artery Structure
Entire Portal Vein
Intravenous Injections
Entire Trunk of Portal Vein
Portal Vein Structure
Adrenergic alpha-Antagonists

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