Epinephrine promotes hemostasis in rats with cyclophosphamide-induced hemorrhagic cystitis

Urology
Yung-Chiong ChowPaulus S Wang

Abstract

To evaluate the hypothesis that intravesical instillation of epinephrine would attenuate bladder hemorrhage in a rat model of cyclophosphamide (CYP)-induced hemorrhagic cystitis. Female Sprague-Dawley rats were divided into seven treatment groups: positive control (CYP, 150 mg/kg), negative control (epinephrine, 10 microg/mL), intravesical instillation of normal saline (vehicle) and epinephrine (2.5, 5, and 10 microg/mL), and intraperitoneal administration of mesna (50 mg/kg). Rats were killed on days 1, 2, and 3, and the urinary bladders were removed, weighed, and evaluated by gross and histologic analysis. Vesical vascular permeability was determined by wet bladder weight and Evan's blue dye absorbance. Cyclophosphamide administration induced severe hemorrhagic cystitis with marked edema, hemorrhage, and inflammation. All three epinephrine-treated groups had marked attenuation of hemorrhagic cystitis compared with the positive and negative control and mesna-treated groups. Epinephrine was also associated with significant inhibition of tissue edema, indicating decreased vesical vascular permeability. In this rat model of CYP-induced hemorrhagic cystitis, intravesical instillation of epinephrine inhibited edema, hemorrhage, and...Continue Reading

Citations

May 31, 2014·BioMed Research International·Gilho LeeDaša Zupančič
Jul 9, 2014·Current Opinion in Supportive and Palliative Care·Anwar M AlesawiFred Saad
Sep 25, 2014·International Urology and Nephrology·Ibrahim KelesMehmet Emin Buyukokuroglu
Jul 27, 2011·Naunyn-Schmiedeberg's Archives of Pharmacology·Vinícios T BoeiraFernanda B Morrone
May 29, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Yoon Soo KyungGilho Lee
Jul 12, 2013·Journal of Pharmacological Sciences·Sweety NasrinShizuo Yamada
Oct 2, 2015·Human & Experimental Toxicology·H ParkG Lee
Feb 26, 2008·Experimental Biology and Medicine·Ahmet KorkmazSükrü Oter
Jun 27, 2021·The Journal of Pharmacy and Pharmacology·Tarek Mohamed Kamal MotawiHanan Muhammad Abd-Elgawad

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