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Epinephrine restores platelet functions inhibited by ticagrelor: A mechanistic approach

European Journal of Pharmacology

Nov 15, 2019

Anne-Céline MartinChristilla Bachelot-Loza

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Abstract

Ticagrelor, an antagonist of the platelet adenosine diphosphate (ADP)-P2Y12 receptor is recommended for patients with acute coronary syndromes. However, ticagrelor exposes to a risk of bleeding, the management of which is challenging because platelet transfusion is ineffective, and no a...read more

Mentioned in this Paper

Adenosine Diphosphate
Receptors, Purinergic P1
Antidote
Blood Platelets
Blood Transfusion
Epinephrine
Hemorrhage
Phosphorylation
Platelet Aggregation
Vasoconstrictor Agents
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Epinephrine restores platelet functions inhibited by ticagrelor: A mechanistic approach

European Journal of Pharmacology

Nov 15, 2019

Anne-Céline MartinChristilla Bachelot-Loza

PMID: 31738933

DOI: 10.1016/j.ejphar.2019.172798

Abstract

Ticagrelor, an antagonist of the platelet adenosine diphosphate (ADP)-P2Y12 receptor is recommended for patients with acute coronary syndromes. However, ticagrelor exposes to a risk of bleeding, the management of which is challenging because platelet transfusion is ineffective, and no a...read more

Mentioned in this Paper

Adenosine Diphosphate
Receptors, Purinergic P1
Antidote
Blood Platelets
Blood Transfusion

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