Epinephrine Use during Newborn Resuscitation

Frontiers in Pediatrics
Vishal S Kapadia, Myra H Wyckoff

Abstract

Epinephrine use in the delivery room for resuscitation of the newborn is associated with significant morbidity and mortality. Evidence for optimal dose, timing, and route of administration of epinephrine during neonatal resuscitation comes largely from extrapolated adult or animal literature. In this review, we provide the current recommendations for use of epinephrine during neonatal resuscitation and also the evidence behind these recommendations. In addition, we review the current proposed mechanism of action of epinephrine during neonatal resuscitation, review its adverse effects, and identify gaps in knowledge requiring urgent research.

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Citations

Dec 5, 2018·Minerva pediatrica·Megan O'reilly, Georg M Schmölzer
Mar 14, 2019·Journal of Tissue Engineering and Regenerative Medicine·Sindhuja D EswaramoorthySubha N Rath
Oct 2, 2019·Hospital Pediatrics·Kate D BruneGary M Weiner
Jun 21, 2018·Paediatric Drugs·Roberto AntonucciLaura Cuzzolin
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Oct 23, 2020·Hospital Pediatrics·Kate D BruneGary M Weiner
Oct 21, 2020·Resuscitation·Cecilie HallingUNKNOWN American Heart Association’s Get With The Guidelines–Resuscitation Investigators
Oct 29, 2019·Neonatology·Alexandra ScrivensCharles Christoph Roehr

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