EpiNet as a way of involving more physicians and patients in epilepsy research: Validation study and accreditation process

Epilepsia Open
Peter BerginEpiNet Study Group

Abstract

EpiNet was established to encourage epilepsy research. EpiNet is used for multicenter cohort studies and investigator-led trials. Physicians must be accredited to recruit patients into trials. Here, we describe the accreditation process for the EpiNet-First trials. Physicians with an interest in epilepsy were invited to assess 30 case scenarios to determine the following: whether patients have epilepsy; the nature of the seizures (generalized, focal); and the etiology. Information was presented in two steps for 23 cases. The EpiNet steering committee determined that 21 cases had epilepsy. The steering committee determined by consensus which responses were acceptable for each case. We chose a subset of 18 cases to accredit investigators for the EpiNet-First trials. We initially focused on 12 cases; to be accredited, investigators could not diagnose epilepsy in any case that the steering committee determined did not have epilepsy. If investigators were not accredited after assessing 12 cases, 6 further cases were considered. When assessing the 18 cases, investigators could be accredited if they diagnosed one of six nonepilepsy patients as having possible epilepsy but could make no other false-positive errors and could make only o...Continue Reading

References

Jan 1, 1992·Clinical Neurology and Neurosurgery·W A HoefnagelsR A Roos
Feb 1, 1989·Neurology·C A van DonselaarA Staal
Jan 27, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·H StroinkUNKNOWN Dutch Study of Epilepsy in Childhood
Feb 19, 2008·Epilepsy & Behavior : E&B·Hanneke M de BoerJosemir W Sander
Mar 1, 2012·Epilepsy Currents·Jacqueline A French
May 20, 2015·Epilepsia·Peter S BerginWendyl J D'Souza
Mar 10, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ettore Beghi
Jun 2, 2016·The New England Journal of Medicine·Louis D Fiore, Philip W Lavori

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