Epineurial microvasculitis in proximal diabetic neuropathy

Journal of Neurology
J G LlewelynR H King

Abstract

Amongst the focal and multifocal neuropathies that are associated with diabetes mellitus one of the most common is a proximal predominantly motor lower limb neuropathy. Recent evidence has indicated that, at least in a proportion of cases, this may have an inflammatory basis. We have examined a consecutive series of 15 cases of proximal diabetic neuropathy (diabetic amyotrophy). These were characterized by proximal pain and asymmetric proximal or generalized lower limb muscle weakness, associated in some cases with radicular sensory involvement. Two-thirds of the patients had an accompanying distal symmetric sensory polyneuropathy. Biopsy of the intermediate cutaneous nerve of the thigh, a sensory branch of the femoral nerve, showed epineurial microvasculitis in 3 patients and nonvasculitic epineurial inflammatory infiltrates in another case. In a further case, microvasculitis was found in both in the sural nerve and a quadriceps muscle biopsy specimen. The detection of inflammatory changes appeared to be correlated with the occurrence of sensory radicular involvement. Whether similar changes are present in muscle nerves in this predominantly motor syndrome requires further study. Nevertheless, the present observations confirm ...Continue Reading

References

Sep 1, 1977·Annals of Neurology·A K Asbury
Feb 1, 1976·Neurology·I R Williams, R F Mayer
Jul 1, 1971·Stain Technology·J Sievers
Apr 1, 1973·Journal of Neuropathology and Experimental Neurology·A K Asbury
Jul 4, 1968·The New England Journal of Medicine·M C Raff, A K Asbury
Oct 1, 1974·Journal of Neurology, Neurosurgery, and Psychiatry·B Smith
Mar 11, 1972·British Medical Journal·E B Casey, M J Harrison
Aug 1, 1970·Journal of Neurology, Neurosurgery, and Psychiatry·A Lamontagne, F Buchthal
Feb 1, 1968·Journal of Neurology, Neurosurgery, and Psychiatry·J S Chopra, L J Hurwitz
May 1, 1968·Archives of Neurology·M C RaffA K Asbury
Feb 1, 1980·Annals of Internal Medicine·L W DuchenJ D Mackay
Feb 1, 1982·Journal of the Neurological Sciences·S H Subramony, A J Wilbourn
Sep 1, 1982·Diabetes·A A Sima, P Thibert
May 1, 1981·Veterinary Pathology·G KrinkeR Hess
Dec 1, 1994·Journal of the Neurological Sciences·E Tamura, G J Parry
May 1, 1994·Annals of Neurology·G SaidA Moulonguet
Oct 1, 1996·Journal of the Neurological Sciences·J D StewartG Karpati
Nov 10, 1998·Journal of Neurology·D A Krendel
Jun 27, 1953·British Medical Journal·H GARLAND, D TAVERNER
Nov 26, 1955·British Medical Journal·H GARLAND
Nov 1, 1960·Neurology·J R CALVERLEY, D W MULDER
Feb 1, 1962·Journal of Neurology, Neurosurgery, and Psychiatry·R W GILLIATT, R G WILLISON
Feb 1, 1963·Neurology·C L DOLMAN

❮ Previous
Next ❯

Citations

Dec 8, 2007·Acta Neuropathologica·Nobutoshi KawamuraPeter J Dyck
Feb 5, 2011·Acta Neuropathologica·Jean-Michel VallatLaurent Magy
Mar 20, 2003·Current Diabetes Reports·Rayaz A Malik
Feb 9, 2006·Current Treatment Options in Neurology·Kenneth C Gorson
Sep 16, 2010·Current Treatment Options in Neurology·Pariwat Thaisetthawatkul, P James B Dyck
Sep 22, 2010·Brain : a Journal of Neurology·Haruki Koike, Gen Sobue
Jan 1, 2009·BMJ Case Reports·Yuichi KawagashiraGen Sobue
Jul 20, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Y KawagashiraG Sobue
Nov 12, 1998·Journal of Neurology, Neurosurgery, and Psychiatry·P J Watkins, P K Thomas
Sep 3, 2011·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Jayadave Shakher, Martin J Stevens
Nov 30, 2013·Endocrinology and Metabolism Clinics of North America·Aaron I VinikHenri Parson
May 7, 2013·Neurologic Clinics·Michael P CollinsJohn T Kissel
Jul 16, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yuichi KawagashiraGen Sobue
Jan 16, 2008·Physical Medicine and Rehabilitation Clinics of North America·Jennifer A Tracy, P James B Dyck
Jul 24, 2004·Journal of the American Geriatrics Society·Peter A Engel, Jiang Qian
Jun 23, 2011·Diabetes/metabolism Research and Reviews·Peter J DyckUNKNOWN Toronto Expert Panel on Diabetic Neuropathy
Mar 23, 2011·Annals of Neurology·Mercedes Garces-SanchezP James B Dyck
May 11, 2012·Journal of the Peripheral Nervous System : JPNS·Vera Bril
Sep 22, 2009·Muscle & Nerve·Marta LucchettaChiara Briani
Jun 15, 2010·Muscle & Nerve·Michael P CollinsJohn T Kissel
Aug 17, 2004·The Medical Clinics of North America·A I Vinik, Anahit Mehrabyan
Aug 26, 2014·BioMed Research International·Braca KundalićVladimir Antić
May 27, 2004·Diabetes Care·Andrew J M BoultonJay M Sosenko
Apr 28, 2017·Nature Reviews. Neurology·Michael P Collins, Robert D Hadden
Mar 18, 2008·Arquivos de neuro-psiquiatria·Gérard Said
Jul 27, 2017·The Cochrane Database of Systematic Reviews·Yee Cheun ChanEdwin Sy Chan
Jan 12, 2007·The Neurologist·Kenneth C Gorson
Jun 6, 2007·Nature Clinical Practice. Neurology·Gérard Said
Sep 16, 2017·Nature Reviews. Neurology·Yusuf A RajaballyRayaz A Malik
Jul 18, 2019·Current Opinion in Neurology·Michael P CollinsRobert D M Hadden
Sep 28, 2002·Current Opinion in Neurology·Zachary Simmons, Eva L Feldman
Sep 16, 2004·Current Opinion in Neurology·Michael P Collins, M Isabel Periquet
Nov 11, 2017·The Journal of Clinical Endocrinology and Metabolism·Eugene J BarrettCarolina M Casellini
Dec 11, 1999·Current Opinion in Neurology·G Said
Jun 13, 2000·Journal of Neuropathology and Experimental Neurology·P J DyckP J Dyck
Jan 23, 2021·Diabetes Care·Ari BreinerPierre R Bourque
Nov 10, 2021·Expert Review of Clinical Immunology·Norman Latov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.