Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tyrosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4

Oncogene
T KomurasakiS Morimoto

Abstract

Epiregulin is a member of the epidermal growth factor (EGF) family, and has certain characteristics that are different from that of EGF, including mitogenic responses and binding to EGF receptor (EGFR). Epiregulin may also have another cell surface receptor and/or induces different receptor heterodimerizations for intracellular signaling. We investigated the binding ability of epiregulin to four ErbB family receptors using four human breast carcinoma cell lines that expressed different subsets of receptors. Chemical cross-linking experiments showed that [125I]epiregulin directly bound to each of EGFR and ErbB-4 but not to ErbB-2 and ErbB-3. Furthermore, although epiregulin stimulated tyrosine phosphorylation of all four ErbB receptors, the main intracellular signal was mediated by ErbB-4 and/or EGFR. The pattern of activation of ErbB family receptors was different from that of other EGF-related ligands. Our findings indicate that ErbB-4 and EGFR are receptors for epiregulin, and suggest that EGF-related ligands transduce signals for different biological responses by the hierarchical mechanism.

Citations

Feb 14, 1998·International Journal of Cancer. Journal International Du Cancer·H ModjtahediC Dean
Aug 5, 2000·International Journal of Cancer. Journal International Du Cancer·A deFazioR L Sutherland
Apr 3, 2002·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·W Zhou, G Carpenter
May 6, 2008·Journal of Mammary Gland Biology and Neoplasia·Maria SundvallKlaus Elenius
Mar 22, 2003·Experimental Cell Research·Graham Carpenter
May 8, 2013·Journal of Proteome Research·Emma Yue ZhangWilliam S Hancock
Mar 5, 1999·Breast Cancer Research and Treatment·W J Gullick, R Srinivasan
May 15, 2013·Proceedings of the National Academy of Sciences of the United States of America·Bhuminder SinghRobert J Coffey
Oct 7, 2008·Human Reproduction·I Ben-AmiA Amsterdam
Apr 3, 2001·Annual Review of Neuroscience·R Wechsler-Reya, M P Scott
Sep 16, 2006·Biological Chemistry·Jennifer J SchlezingerDavid H Sherr
Mar 6, 2012·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Mette K NedergaardHans S Poulsen
Jul 13, 2000·Biochemical and Biophysical Research Communications·Z ZhuM Korc
Feb 22, 2001·Biochemical and Biophysical Research Communications·Y YamanakaK Sobue
Nov 13, 2013·Annual Review of Physiology·Bhuminder Singh, Robert J Coffey
Mar 19, 2014·Seminars in Cell & Developmental Biology·David J Riese, Richard L Cullum
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·D S TaylorC J Molloy
Jan 29, 2014·Neuro-oncology·Shinji KohsakaShinya Tanaka
Apr 22, 2014·Nucleic Acids Research·Shalmali Avinash PradhanArun Kumar
Apr 24, 1999·FEBS Letters·J T JonesM X Sliwkowski
Feb 20, 2016·Molecular Carcinogenesis·Alison K BauerRana Brooks
Jan 19, 2016·Biochemical and Biophysical Research Communications·Shogo OkazakiOsamu Nagano
Oct 25, 2008·Biochemical and Biophysical Research Communications·Min-Chul ChoDo-Young Yoon
Aug 5, 2003·Journal of Cellular Biochemistry·Bradley K DraperLillian B Nanney
May 20, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Bradley K DraperLillian B Nanney
Sep 13, 2007·Molecular Carcinogenesis·Fadel S AlyaqoubMichael A Pereira
Dec 21, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Koichi NagaiKazuo Komiyama
Jul 1, 2009·Biochemical and Biophysical Research Communications·Meng ZhaoRong-guang Shao
Apr 2, 2004·Pharmacology & Therapeutics·Jennifer Rubin Grandis, John C Sok
Aug 21, 2013·Biomaterials·Chetan YewaleAmbikanandan Misra
Oct 23, 2003·The Journal of Biological Chemistry·Bon-Hun Koo, Doo-Sik Kim
May 26, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·David HsuMaria T Abreu
Apr 18, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jiyeon YunTae-You Kim
Mar 30, 2001·The Journal of Biological Chemistry·L StrachanK D Kumble

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