Epiretinal transplantation of human bone marrow mesenchymal stem cells rescues retinal and vision function in a rat model of retinal degeneration

Stem Cell Research
Adi TzameretArieh S Solomon

Abstract

Vision incapacitation and blindness associated with incurable retinal degeneration affect millions of people worldwide. In this study, 0.25×10(6) human bone marrow stem cells (hBM-MSCs) were transplanted epiretinally in the right eye of Royal College Surgeons (RCS) rats at the age of 28 days. Epiretinally transplanted cells were identified as a thin layer of cells along vitreous cavity, in close proximity to the retina or attached to the lens capsule, up to 6 weeks following transplantation. Epiretinal transplantation delayed photoreceptor degeneration and rescued retinal function up to 20 weeks following cell transplantation. Visual functions remained close to normal levels in epiretinal transplantation rats. No inflammation or any other adverse effects were observed in transplanted eyes. Our findings suggest that transplantation of hBM-MSCs as a thin epiretinal layer is effective for treatment of retinal degeneration in RCS rats, and that transplanting the cells in close proximity to the retina enhances hBM-MSC therapeutic effect compared with intravitreal injection.

References

Mar 4, 2000·Human Molecular Genetics·P M D'CruzD Vollrath
Aug 14, 2003·Human Molecular Genetics·Dervila GlynnA Jennifer Morton
Sep 6, 2005·Blood·Anna CorcioneAntonio Uccelli
Aug 10, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·S ArnholdU Schraermeyer
Nov 22, 2008·The Journal of Pathology·A I Caplan
Dec 18, 2008·Experimental Eye Research·Bin LinEnrica Strettoi
Mar 10, 2010·Nature Reviews. Genetics·Alan F WrightShomi S Bhattacharya
Sep 14, 2011·Archives of Ophthalmology·T Michael NorkBrian J Christian
Jan 28, 2012·Lancet·Steven D SchwartzRobert Lanza
Sep 14, 2012·Frontiers in Physiology·Serena Rubina BaglioNicola Baldini
May 30, 2013·Development·Conor M RamsdenPeter J Coffey
Aug 31, 2013·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Marc D de SmetAeilko H Zwinderman
Jan 1, 2014·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yoshitsugu Obi, Takayuki Hamano
Mar 13, 2014·International Journal of Molecular Sciences·Bo YuXiaorong Li
Apr 29, 2014·World Journal of Stem Cells·Tsz Kin NgHerman S Cheung

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Citations

Apr 13, 2019·International Journal of Molecular Sciences·Shirley Suet Lee DingPooi Ling Mok
Dec 9, 2017·Reviews in the Neurosciences·Suleiman Alhaji MuhammadSharida Fakurazi
May 17, 2017·Journal of Neuroscience Research·Hiromi MuraseHideaki Hara
Nov 21, 2017·Current Molecular Biology Reports·Sujoy BhattacharyaEdward Chaum
Aug 10, 2017·International Journal of Molecular Sciences·Suet Lee Shirley DingPooi Ling Mok
May 11, 2017·Journal of Translational Medicine·Zhimin TangPing Gu
Oct 4, 2020·International Journal of Molecular Sciences·Johnny Di PierdomenicoMaría P Villegas-Pérez
Dec 3, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Martina PesaresiMaria Pia Cosma
Oct 4, 2020·Experimental Eye Research·Chang-Jun ZhangZi-Bing Jin
Apr 28, 2021·Stem Cell Reviews and Reports·Maria Luz Alonso-AlonsoYolanda Diebold
Jul 3, 2021·Pharmaceutics·Liron Naftali Ben Haim, Elad Moisseiev

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