Episodes of fever and neutropenia in children with cancer in a tertiary care medical center in Turkey

Pediatric Hematology and Oncology
Gulsun TezcanVolkan Hazar

Abstract

The aim of this study was to determine the clinical features and microbiological spectrum during episodes of fever and neutropenia (FEN) in children with cancer. Demographics, clinical information, treatment approaches, and outcomes of the patients admitted to Akdeniz University Department of Pediatric Hematology and Oncology from October 1996 to June 2004 were evaluated retrospectively. Of the total 621 episodes, 345 (55.5%) were microbiologically documented (MDI) (36.4%) or clinically suspected (CSI) (19.2%) infections. A total of 425 infections were diagnosed in 345 episodes, in which lower respiratory tract infections were the most common (32.7%). Among the microbiologically documented infections, Staphylococci (both coagulase-negative and coagulase-positive) (38.7%) and Escherichia coli (12.9%) were the most frequently isolated gram-positive and gram-negative organisms, respectively. Monocytopenia less than 100/microL (p = 0.01), duration of neutropenia (p = .01) and fever (p < .001) were significantly associated with documented infection by univariate analysis. In addition, presence of previous FEN episode (p = .001) and hypotension (p = .029) were also found to be risk factors. However, using the multivariate analyses, o...Continue Reading

References

Mar 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W R RackoffP B Breitfeld
Mar 1, 1996·Infectious Disease Clinics of North America·G R Donowitz
May 1, 1996·Pediatric Hematology and Oncology·G R JonesS N Pusek
Nov 1, 1996·Pediatric Hematology and Oncology·A RoguinM Berant
Oct 6, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W T HughesL S Young
Sep 7, 1999·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K V Rolston, J J Tarrand
Apr 17, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·L A MermelUNKNOWN Society for Healthcare Epidemiology of America
Jul 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M E SantolayaM Zubieta
Nov 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R HauptE Castagnola
Feb 19, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Walter T HughesLowell S Young
Jul 13, 2002·Medical and Pediatric Oncology·Elmar Orudjev, Beverly J Lange

❮ Previous
Next ❯

Citations

Oct 16, 2010·Pediatric Blood & Cancer·I L M KlaassenA Bökenkamp
Jul 14, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Bob PhillipsAlex J Sutton
Sep 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas LehrnbecherUNKNOWN International Pediatric Fever and Neutropenia Guideline Panel
Sep 7, 2017·The Pediatric Infectious Disease Journal·Gabrielle M HaeuslerRobert Phillips
Sep 18, 2008·Journal of Pediatric Hematology/oncology·Barş ErdurGülersu Irken
Jun 24, 2008·Pediatric Hematology and Oncology·Sameer BakhshiL S Arya
Aug 7, 2009·Pediatric Hematology and Oncology·Manuel Martinez-AlbarranOscar Gonzalez-Ramella
Apr 25, 2008·Pediatric Hematology and Oncology·Sebnem YilmazGülersu Irken
Mar 27, 2009·Pediatric Hematology and Oncology·Sebnem YilmazGülersu Irken

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.