Episodic memory retrieval success is associated with rapid replay of episode content.

Nature Neuroscience
G Elliott WimmerR. J. Dolan

Abstract

Retrieval of everyday experiences is fundamental for informing our future decisions. The fine-grained neurophysiological mechanisms that support such memory retrieval are largely unknown. We studied participants who first experienced, without repetition, unique multicomponent 40-80-s episodes. One day later, they engaged in cued retrieval of these episodes while undergoing magnetoencephalography. By decoding individual episode elements, we found that trial-by-trial successful retrieval was supported by the sequential replay of episode elements, with a temporal compression factor of >60. The direction of replay supporting retrieval, either backward or forward, depended on whether the task goal was to retrieve elements of an episode that followed or preceded, respectively, a retrieval cue. This sequential replay was weaker in very-high-performing participants, in whom instead we found evidence for simultaneous clustered reactivation. Our results demonstrate that memory-mediated decisions are supported by a rapid replay mechanism that can flexibly shift in direction in response to task goals.

References

Jul 1, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D Marr
Sep 1, 1997·IEEE Transactions on Bio-medical Engineering·B D Van VeenA Suzuki
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·M E WheelerR L Buckner
Dec 24, 2002·Neuron·Albert K Lee, Matthew A Wilson
Dec 24, 2005·Science·Sean M PolynKenneth A Norman
Apr 7, 2007·Science·Dorothy TseRichard G M Morris
Sep 11, 2007·Nature Neuroscience·Kamran Diba, György Buzsáki
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam Johnson, A David Redish
Jul 1, 1948·Psychological Review·E C TOLMAN
Jun 17, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Aya Ben-Yakov, Yadin Dudai
May 5, 2012·Science·Shantanu P JadhavLoren M Frank
Oct 16, 2012·Science·G Elliott Wimmer, Daphna Shohamy
Jan 29, 2013·Nature Neuroscience·György Buzsáki, Edvard I Moser
Apr 19, 2013·Nature·Brad E Pfeiffer, David J Foster
Aug 22, 2013·Frontiers in Psychology·Rogier A KievitDenny Borsboom
Oct 22, 2013·Neuron·Ray J Dolan, Peter Dayan
Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Arielle Tambini, Lila Davachi
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lorena DeukerNikolai Axmacher
Jan 2, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anna JafarpourEmrah Duzel
Nov 8, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·G Elliott WimmerDaphna Shohamy
Jan 7, 2015·Nature Neuroscience·Andrew M Wikenheiser, A David Redish
Jan 24, 2015·ELife·Zeb Kurth-NelsonPeter Dayan
Jul 3, 2015·Nature Communications·Aidan J HornerNeil Burgess
Mar 11, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·G Elliott Wimmer, Christian Büchel
Jun 3, 2016·Neuron·Michael N Shadlen, Daphna Shohamy
Jun 11, 2016·Science·Thackery I BrownAnthony D Wagner
Jun 19, 2016·Trends in Cognitive Sciences·Dharshan KumaranJames L McClelland
Jun 21, 2016·Neuron·Zeb Kurth-NelsonPeter Dayan
Feb 6, 2017·Journal of Neurophysiology·Howard Eichenbaum
Mar 25, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert B YaffeKareem A Zaghloul
Jan 10, 2018·Current Biology : CB·H Freyja ÓlafsdóttirCaswell Barry
Oct 26, 2018·Neuron·Timothy E J BehrensZeb Kurth-Nelson
Apr 5, 2019·Nature Human Behaviour·Sebastian MichelmannSimon Hanslmayr
Jun 13, 2019·Nature Communications·G Elliott Wimmer, Christian Büchel
Jun 30, 2019·Science·Nicolas W Schuck, Yael Niv
Jul 4, 2019·ELife·Akram BakkourDaphna Shohamy
Jul 10, 2019·Cell·Yunzhe LiuTimothy E J Behrens

❮ Previous
Next ❯

Citations

Jun 13, 2020·Journal of Cognitive Neuroscience·Jacob L S BellmundChristian F Doeller
Apr 10, 2021·NeuroImage·Dazhi Yin, Marcus Kaiser
May 22, 2021·Science·Yunzhe LiuRaymond J Dolan
Apr 23, 2021·ELife·Caroline S LeeChristopher Baldassano
Jul 2, 2021·Cell·Matthew M NourRaymond J Dolan
Oct 13, 2020·Trends in Neurosciences·Serra E FavilaBrice A Kuhl
Oct 1, 2021·Annual Review of Psychology·Jon S SimonsCharles Fernyhough

❮ Previous
Next ❯

Software Mentioned

OHBA Software Library
R
lmer4
Matlab
Eyelink
bobyqa
SPM12
FieldTrip
OSL

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

BioRxiv : the Preprint Server for Biology
G Elliott WimmerR. J. Dolan
Reumatología clinica
Leobardo Terán Estrada
Obstetrics and Gynecology
Ankita GuptaSean Francis
Obstetrics and Gynecology
Catherine M Leclair, Christopher M Zahn
Obstetrics and Gynecology
Federica BellussiVincenzo Berghella
© 2022 Meta ULC. All rights reserved