Flies are one of four superradiations of insects (along with beetles, wasps, and moths) that account for the majority of animal life on Earth. Diptera includes species known for their ubiquity (Musca domestica house fly), their role as pests (Anopheles gambiae malaria mosquito), and their value as model organisms across the biological sciences (Drosophila melanogaster). A resolved phylogeny for flies provides a framework for genomic, developmental, and evolutionary studies by facilitating comparisons across model organisms, yet recent research has suggested that fly relationships have been obscured by multiple episodes of rapid diversification. We provide a phylogenomic estimate of fly relationships based on molecules and morphology from 149 of 157 families, including 30 kb from 14 nuclear loci and complete mitochondrial genomes combined with 371 morphological characters. Multiple analyses show support for traditional groups (Brachycera, Cyclorrhapha, and Schizophora) and corroborate contentious findings, such as the anomalous Deuterophlebiidae as the sister group to all remaining Diptera. Our findings reveal that the closest relatives of the Drosophilidae are highly modified parasites (including the wingless Braulidae) of bees...Continue Reading
Estimating absolute rates of molecular evolution and divergence times: a penalized likelihood approach
Evolution and phylogenetic utility of CAD (rudimentary) among Mesozoic-aged Eremoneuran Diptera (Insecta)
RAxML-VI-HPC: maximum likelihood-based phylogenetic analyses with thousands of taxa and mixed models
The phylogeny and evolution of host choice in the Hippoboscoidea (Diptera) as reconstructed using four molecular markers
Evolutionary origin of the amnioserosa in cyclorrhaphan flies correlates with spatial and temporal expression changes of zen
Evidence for a composite anterior determinant in the hover fly Episyrphus balteatus (Syrphidae), a cyclorrhaphan fly with an anterodorsal serosa anlage
Ecological limits and diversification rate: alternative paradigms to explain the variation in species richness among clades and regions
A multigene phylogeny of the fly superfamily Asiloidea (Insecta): Taxon sampling and additional genes reveal the sister-group to all higher flies (Cyclorrhapha)
Evaluation of the internal transcribed spacer 2 (ITS2) as a molecular marker for phylogenetic inference using sequence and secondary structure information in blow flies (Diptera: Calliphoridae)
Sensilla on antenna and maxillary palp of predaceous fly, Lispe neimongola Tian et Ma (Diptera: Muscidae)
The molecular systematics of blowflies and screwworm flies (Diptera: Calliphoridae) using 28S rRNA, COX1 and EF-1α: insights into the evolution of dipteran parasitism
Mitochondrial genome sequences of Nematocera (lower Diptera): evidence of rearrangement following a complete genome duplication in a winter crane fly
On the origin of the eukaryotic chromosome: the role of noncanonical DNA structures in telomere evolution
Genomic, RNAseq, and molecular modeling evidence suggests that the major allergen domain in insects evolved from a homodimeric origin
The Enhancer of split complex arose prior to the diversification of schizophoran flies and is strongly conserved between Drosophila and stalk-eyed flies (Diopsidae)
Widespread and persistent invasions of terrestrial habitats coincident with larval feeding behavior transitions during snail-killing fly evolution (Diptera: Sciomyzidae)
The evolutionary host switches of Polychromophilus: a multi-gene phylogeny of the bat malaria genus suggests a second invasion of mammals by a haemosporidian parasite
Co-option of a coordinate system defined by the EGFr and Dpp pathways in the evolution of a morphological novelty
The complete mitochondrial genome and novel gene arrangement of the unique-headed bug Stenopirates sp. (Hemiptera: Enicocephalidae)
Higher level phylogeny and the first divergence time estimation of Heteroptera (Insecta: Hemiptera) based on multiple genes
Peptidomics of the agriculturally damaging larval stage of the cabbage root fly Delia radicum (Diptera: Anthomyiidae)
Evolutionary history of assassin bugs (insecta: hemiptera: Reduviidae): insights from divergence dating and ancestral state reconstruction
The first mitochondrial genome for the fishfly subfamily Chauliodinae and implications for the higher phylogeny of Megaloptera
Phylogeny of the Archiborborinae (Diptera: Sphaeroceridae) based on combined morphological and molecular analysis
A large-scale, higher-level, molecular phylogenetic study of the insect order Lepidoptera (moths and butterflies)
The mitochondrial genome of Elodia flavipalpis Aldrich (Diptera: Tachinidae) and the evolutionary timescale of Tachinid flies
Global transcriptome analysis of orange wheat blossom midge, Sitodiplosis mosellana (Gehin) (Diptera: Cecidomyiidae) to identify candidate transcripts regulating diapause
Can RNA-Seq resolve the rapid radiation of advanced moths and butterflies (Hexapoda: Lepidoptera: Apoditrysia)? An exploratory study
A pipeline for the de novo assembly of the Themira biloba (Sepsidae: Diptera) transcriptome using a multiple k-mer length approach
Aquatic macroinvertebrate assemblages of Ghana, West Africa: understanding the ecology of a neglected tropical disease
Evidence for deep regulatory similarities in early developmental programs across highly diverged insects
Checklist of the familes Chaoboridae, Dixidae, Thaumaleidae, Psychodidae and Ptychopteridae (Diptera) of Finland
Heterochronic shifts in germband movements contribute to the rapid embryonic development of the coffin fly Megaselia scalaris
Divergent and conserved elements comprise the chemoreceptive repertoire of the nonblood-feeding mosquito Toxorhynchites amboinensis
Reassessment of Paleotachina Townsend and Electrotachina Townsend and their removal from the Tachinidae (Diptera)
Checklist of the Diptera families Acartophthalmidae, Canacidae (including Tethinidae), Carnidae and Milichiidae of Finland (Insecta)
Checklist of the braulidae, camillidae, diastatidae and drosophilidae of Finland (Diptera, ephydroidea)
The mushroom bodies of the lower nematocera: a link between those of the higher Diptera and other mecopteroids
Cloning and characterization of the peptidoglycan recognition protein genes in the mosquito, Armigeres subalbatus (Diptera: Culicidae)
Molecular systematics of the Calliphoridae (Diptera: Oestroidea): evidence from one mitochondrial and three nuclear genes
Evolution of herbivory in Drosophilidae linked to loss of behaviors, antennal responses, odorant receptors, and ancestral diet
A massive expansion of effector genes underlies gall-formation in the wheat pest Mayetiola destructor
Where do the Neotropical Empidini lineages (Diptera: Empididae: Empidinae) fit in a worldwide context?
The skeletomuscular system of the larva of Drosophila melanogaster (Drosophilidae, Diptera): a contribution to the morphology of a model organism
A molecular phylogeny for the Tribe Dacini (Diptera: Tephritidae): systematic and biogeographic implications
Phylogenetic analyses suggest that diversification and body size evolution are independent in insects
Phylogenomic methods outperform traditional multi-locus approaches in resolving deep evolutionary history: a case study of formicine ants
Duplication and Diversification of Dipteran Argonaute Genes, and the Evolutionary Divergence of Piwi and Aubergine
A de novo transcriptome of the Malpighian tubules in non-blood-fed and blood-fed Asian tiger mosquitoes Aedes albopictus: insights into diuresis, detoxification, and blood meal processing
Effects of permissible maximum-contamination levels of VOC mixture in water on total DNA, antioxidant gene expression, and sequences of ribosomal DNA of Drosophila melanogaster
First μ-CT-based 3D reconstruction of a dipteran larva-the head morphology of Protanyderus (Tanyderidae) and its phylogenetic implications
Dramatic expansion and developmental expression diversification of the methuselah gene family during recent Drosophila evolution
Evolution of habitat preference and nutrition mode in a cosmopolitan fungal genus with evidence of interkingdom host jumps and major shifts in ecology
Novel arrangement and comparative analysis of hsp90 family genes in three thermotolerant species of Stratiomyidae (Diptera)
Fossils and a large molecular phylogeny show that the evolution of species richness, generic diversity, and turnover rates are disconnected
Toward a study of gene regulatory constraints to morphological evolution of the Drosophila ocellar region
The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera
Morphogenetic characterisation, date of divergence, and evolutionary relationships of malaria vectors Anopheles cruzii and Anopheles homunculus
Say goodbye to tribes in the new house fly classification: A new molecular phylogenetic analysis and an updated biogeographical narrative for the Muscidae (Diptera)
Beyond barcoding: a mitochondrial genomics approach to molecular phylogenetics and diagnostics of blowflies (Diptera: Calliphoridae)
One proboscis, two tasks: adaptations to blood-feeding and nectar-extracting in long-proboscid horse flies (Tabanidae, Philoliche)
Phylogenetic relationship among East Asian species of the Stegana genus group (Diptera, Drosophilidae)
Molecular phylogenetics of Oestroidea (Diptera: Calyptratae) with emphasis on Calliphoridae: insights into the inter-familial relationships and additional evidence for paraphyly among blowflies
INSECT PHYLOGENOMICS. Comment on "Phylogenomics resolves the timing and pattern of insect evolution"
Germ line transformation and in vivo labeling of nuclei in Diptera: report on Megaselia abdita (Phoridae) and Chironomus riparius (Chironomidae)
Explosive radiation or uninformative genes? Origin and early diversification of tachinid flies (Diptera: Tachinidae)
Sex-biased Patterns of Saprophagous Calyptratae (Diptera) Collected With Different Baits of Animal Origin
The complete mitochondrial genome of Biston panterinaria (Lepidoptera: Geometridae), with phylogenetic utility of mitochondrial genome in the Lepidoptera
Does better taxon sampling help? A new phylogenetic hypothesis for Sepsidae (Diptera: Cyclorrhapha) based on 50 new taxa and the same old mitochondrial and nuclear markers
The evolution and biogeography of the austral horse fly tribe Scionini (Diptera: Tabanidae: Pangoniinae) inferred from multiple mitochondrial and nuclear genes
Ultrastructural investigation of antennae in three cutaneous myiasis flies: Melophagus ovinus, Hippobosca equina, and Hippobosca longipennis (Diptera: Hippoboscidae)
Identification and functional analysis of the peptidoglycan recognition protein LD gene in the mosquito, Armigeres subalbatus
Serosal cuticle formation and distinct degrees of desiccation resistance in embryos of the mosquito vectors Aedes aegypti, Anopheles aquasalis and Culex quinquefasciatus
Quantitative system drift compensates for altered maternal inputs to the gap gene network of the scuttle fly Megaselia abdita
The comparative study of five sex-determining proteins across insects unveils high rates of evolution at basal components of the sex determination cascade
The Phylogeny and Evolutionary Timescale of Muscoidea (Diptera: Brachycera: Calyptratae) Inferred from Mitochondrial Genomes
Capturing the Phylogeny of Holometabola with Mitochondrial Genome Data and Bayesian Site-Heterogeneous Mixture Models
De novo assembly and transcriptome analysis of the Mediterranean fruit fly Ceratitis capitata early embryos
Anchored enrichment dataset for true flies (order Diptera) reveals insights into the phylogeny of flower flies (family Syrphidae)
Morphology and development rate of the immature stages of Glyphidops (Oncopsia) flavifrons (Bigot, 1886) (Diptera, Neriidae) under natural conditions
Distinct regulation of atonal in a visual organ of Drosophila: Organ-specific enhancer and lack of autoregulation in the larval eye
Catching prey with the antennae - The larval head of Corethrella appendiculata (Diptera: Corethrellidae)
Genome sequence of Phormia regina Meigen (Diptera: Calliphoridae): implications for medical, veterinary and forensic research
Fossil record of stem groups employed in evaluating the chronogram of insects (Arthropoda: Hexapoda)
Gene Ages, Nomenclatures, and Functional Diversification of the Methuselah/Methuselah-Like GPCR Family in Drosophila and Tribolium
Large-scale mitogenomics enables insights into Schizophora (Diptera) radiation and population diversity
Transcriptomes of three species of Tipuloidea (Diptera, Tipulomorpha) and implications for phylogeny of Tipulomorpha
Comparative Mt Genomics of the Tipuloidea (Diptera: Nematocera: Tipulomorpha) and Its Implications for the Phylogeny of the Tipulomorpha
Global patterns of insect diversification: towards a reconciliation of fossil and molecular evidence?
Transient leg deformations during eclosion out of a tight confinement: A comparative study on seven species of flies, moths, ants and bees
The 'dance' of life: visualizing metamorphosis during pupation in the blow fly Calliphora vicina by X-ray video imaging and micro-computed tomography
Functional Validation of Apoptosis Genes IAP1 and DRONC in Midgut Tissue of the Biting Midge Culicoides sonorensis (Diptera: Ceratopogonidae) by RNAi
A Dipteran's Novel Sucker Punch: Evolution of Arthropod Atypical Venom with a Neurotoxic Component in Robber Flies (Asilidae, Diptera)
Drosophila as a developmental paradigm of regressive brain evolution: proof of principle in the visual system
The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species
Cis-regulatory evolution integrated the Bric-à-brac transcription factors into a novel fruit fly gene regulatory network
Decoupling from yolk sac is required for extraembryonic tissue spreading in the scuttle fly Megaselia abdita
X-ray diffraction pattern from the flight muscle of Toxorhynchites towadensis reveals the specific phylogenic position of mosquito among Diptera
Endogenous insensitivity to the Orco agonist VUAA1 reveals novel olfactory receptor complex properties in the specialist fly Mayetiola destructor
Discovery of Novel Crustacean and Cephalopod Flaviviruses: Insights into the Evolution and Circulation of Flaviviruses between Marine Invertebrate and Vertebrate Hosts
Mitochondrial phylogenomics of Hemiptera reveals adaptive innovations driving the diversification of true bugs
Phylogenetic distribution of extant richness suggests metamorphosis is a key innovation driving diversification in insects
The Deadbeat Paternal Effect of Uncapped Sperm Telomeres on Cell Cycle Progression and Chromosome Behavior in Drosophila melanogaster
Shotgun mitogenomics across body size classes in a local assemblage of tropical Diptera: Phylogeny, species diversity and mitochondrial abundance spectrum
Recalibration of the insect evolutionary time scale using Monte San Giorgio fossils suggests survival of key lineages through the End-Permian Extinction
Epsilon glutathione transferases possess a unique class-conserved subunit interface motif that directly interacts with glutathione in the active site
Evolutionary Dynamics of the SKN-1 → MED → END-1,3 Regulatory Gene Cascade in Caenorhabditis Endoderm Specification
Thoracic underreplication in Drosophila species estimates a minimum genome size and the dynamics of added DNA.
The brachyceran de novo gene PIP82, a phosphorylation target of aPKC, is essential for proper formation and maintenance of the rhabdomeric photoreceptor apical domain in Drosophila.
CRISPR/Cas9 and active genetics-based trans-species replacement of the endogenous Drosophila kni -L2 CRM reveals unexpected complexity
The genus Dixa (Diptera, Dixidae) in Croatian lotic habitats, with a checklist of species and relationships with the fauna of neighbouring countries
Towards reconstructing the dipteran demise of an ancient essential gene: E3 ubiquitin ligase Murine double minute
Life history, dormancy regulation, reproductive physiology and basic behaviour of the subtropical fruit fly Rhagoletotrypeta pastranai (Diptera:Tephritidae).
Mitochondrial genomes of two phlebotomine sand flies, Phlebotomus chinensis and Phlebotomus papatasi (Diptera: Nematocera), the first representatives from the family Psychodidae
Analysis of 5' gene regions reveals extraordinary conservation of novel non-coding sequences in a wide range of animals
Pervasive microRNA Duplication in Chelicerates: Insights from the Embryonic microRNA Repertoire of the Spider Parasteatoda tepidariorum
Transcriptomic data from panarthropods shed new light on the evolution of insulator binding proteins in insects : Insect insulator proteins
Skeleton and musculature of the male abdomen in Tanyderidae (Diptera, Nematocera) of the Southern Hemisphere
Embryo polarity in moth flies and mosquitoes relies on distinct old genes with localized transcript isoforms
Expansion of Imaginal Disc Growth Factor Gene Family in Diptera Reflects the Evolution of Novel Functions
Adult neurogenesis in the mushroom bodies of red flour beetles (Tribolium castaneum, HERBST) is influenced by the olfactory environment.
Hidden in Plain Sight: Comprehensive Molecular Phylogeny of Keroplatidae and Lygistorrhinidae (Diptera) Reveals Parallel Evolution and Leads to a Revised Family Classification
First fossil of an oestroid fly (Diptera: Calyptratae: Oestroidea) and the dating of oestroid divergences
Genomic analyses of a livestock pest, the New World screwworm, find potential targets for genetic control programs.
Critical weight mediates sex-specific body size plasticity and sexual dimorphism in the yellow dung fly Scathophaga stercoraria (Diptera: Scathophagidae)
The genome of the biting midge Culicoides sonorensis and gene expression analyses of vector competence for bluetongue virus
The X chromosome of the German cockroach, Blattella germanica, is homologous to a fly X chromosome despite 400 million years divergence
Isoform-specific functions of an evolutionarily conserved 3 bp micro-exon alternatively spliced from another exon in Drosophila homothorax gene
Protein Structure-Guided Hidden Markov Models (HMMs) as A Powerful Method in the Detection of Ancestral Endogenous Viral Elements
Comparisons of Respiratory Pupal Gill Development in Black Flies (Diptera: Simuliidae) Shed Light on the Origin of Dipteran Prothoracic Dorsal Appendages.
Genomic signatures of globally enhanced gene duplicate accumulation in the megadiverse higher Diptera fueling intralocus sexual conflict resolution
Multiple origins of obligate nematode and insect symbionts by a clade of bacteria closely related to plant pathogens.
Diversification of the gut fungi Smittium and allies (Harpellales) co-occurred with the origin of complete metamorphosis of their symbiotic insect hosts (lower Diptera)
Evolutionary insights into bot flies (Insecta: Diptera: Oestridae) from comparative analysis of the mitochondrial genomes
Genetic determinants of antiviral immunity in dipteran insects - Compiling the experimental evidence.
Comparative analysis of the mitochondrial genomes of flesh flies and their evolutionary implication.
A phylogenomic study of Steganinae fruit flies (Diptera: Drosophilidae): strong gene tree heterogeneity and evidence for monophyly
A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons.
Molecular phylogenetic relationships reveal contrasting evolutionary patterns in Gorgoniidae (Octocorallia) in the Eastern Pacific
Anchored phylogenomics unravels the evolution of spider flies (Diptera, Acroceridae) and reveals discordance between nucleotides and amino acids
Phylogenetics of Australasian gall flies (Diptera: Fergusoninidae): Evolutionary patterns of host-shifting and gall morphology
Discovery of a Novel Flavivirus (Flaviviridae) From the Horse Fly, Tabanus rufidens (Diptera: Tabanidae): The Possible Coevolutionary Relationships Between the Classical Insect-Specific Flaviviruses and Host Dipteran Insects.
A maternal effect rough deal mutation suggests that multiple pathways regulate Drosophila RZZ kinetochore recruitment
Museomics and phylogenomics with protein-encoding ultraconserved elements illuminate the evolution of life history and phallic morphology of flesh flies (Diptera: Sarcophagidae).
Discovery of Lebambromyia in Myanmar Cretaceous Amber: Phylogenetic and Biogeographic Implications (Insecta, Diptera, Phoroidea).
Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.
Antimalarial Agents (ASM)
Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.