Epistasis affecting litter size in mice

Journal of Evolutionary Biology
Andrea C PeripatoJames M Cheverud

Abstract

Litter size is an important reproductive trait as it makes a major contribution to fitness. Generally, traits closely related to fitness show low heritability perhaps because of the corrosive effects of directional natural selection on the additive genetic variance. Nonetheless, low heritability does not imply, necessarily, a complete absence of genetic variation because genetic interactions (epistasis and dominance) contribute to variation in traits displaying strong heterosis in crosses, such as litter size. In our study, we investigated the genetic architecture of litter size in 166 females from an F2 intercross of the SM/J and LG/J inbred mouse strains. Litter size had a low heritability (h2 = 12%) and a low repeatability (r = 33%). Using interval-mapping methods, we located two quantitative trait loci (QTL) affecting litter size at locations D7Mit21 + 0 cM and D12Mit6 + 8 cM, on chromosomes 7 and 12 respectively. These QTL accounted for 12.6% of the variance in litter size. In a two-way genome-wide epistasis scan we found eight QTL interacting epistatically involving chromosomes 2, 4, 5, 11, 14, 15 and 18. Taken together, the QTL and their interactions explain nearly 49% (39.5% adjusted multiple r2) of the phenotypic varia...Continue Reading

References

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Citations

Oct 12, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Carolina P GoesAndrea C Peripato
Dec 25, 2010·Behavior Genetics·Robert M HannonTheodore Garland
Mar 27, 2012·Molecular Biotechnology·Jerry WeiPeter Williamson
Jan 1, 2009·Animal : an International Journal of Animal Bioscience·Paul LaissueDaniel Vaiman
Jan 1, 2011·Animal : an International Journal of Animal Bioscience·Joaquim Casellas
Oct 1, 2009·Heredity·W-H WeiD-J de Koning
Jun 7, 2008·The Journal of Heredity·L J LeamyJ Timothy Lightfoot
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May 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Tomas HrbekJames M Cheverud
Dec 19, 2015·Genes, Brain, and Behavior·Xiaofang HeRobert R H Anholt
Mar 11, 2015·The Journal of Veterinary Medical Science·Jun-ichi Suto
Jan 7, 2006·Evolution; International Journal of Organic Evolution·Reinaldo A de BritoJames M Cheverud
Jan 7, 2015·Congenital Anomalies·Keitaro HirawatariHideo Gotoh
May 13, 2015·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Keitaro HirawatariHideo Gotoh
May 29, 2012·American Journal of Human Genetics·Gülüm KosovaCarole Ober
May 9, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Cailu LinDanielle R Reed
Mar 17, 2019·G3 : Genes - Genomes - Genetics·John R ShorterFernando Pardo-Manuel de Villena
Jan 13, 2015·Genetics Research·Joaquim CasellasJuan F Medrano

Related Concepts

Genome Mapping
Crosses, Genetic
Deviation, Epistatic
Litter Size
Mice, Inbred Strains
Selection, Genetic
Variation (Genetics)
Quantitative Trait Loci

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