Epistasis among eNOS, MMP-9 and VEGF maternal genotypes in hypertensive disorders of pregnancy

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Marcelo R LuizonJose E Tanus-Santos

Abstract

Polymorphisms of the endothelial nitric oxide synthase (eNOS), matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) genes were shown to be associated with hypertensive disorders of pregnancy. However, epistasis is suggested to be an important component of the genetic susceptibility to preeclampsia (PE). The aim of this study was to characterize the interactions among these genes in PE and gestational hypertension (GH). Seven clinically relevant polymorphisms of eNOS (T-786C, rs2070744, a variable number of tandem repeats in intron 4 and Glu298Asp, rs1799983), MMP-9 (C-1562T, rs3918242 and -90(CA)₁₃-₂₅, rs2234681) and VEGF (C-2578A, rs699947 and G-634C, rs2010963) were genotyped by TaqMan allelic discrimination assays or PCR and fragment separation by electrophoresis in 122 patients with PE, 107 patients with GH and a control group of 102 normotensive pregnant (NP) women. A robust multifactor dimensionality reduction analysis was used to characterize gene-gene interactions. Although no significant genotype combinations were observed for the comparison between the GH and NP groups (P>0.05), the combination of MMP-9-1562CC with VEGF-634GG was more frequent in NP women than in women with PE (P<0.05). Mor...Continue Reading

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Citations

Oct 16, 2012·DNA and Cell Biology·Ludmila MunizValeria C Sandrim
May 10, 2012·Journal of Pregnancy·Marcelo Rizzatti LuizonValeria Cristina Sandrim
Apr 11, 2013·Pharmacogenomics·Marcelo R Luizon, Valeria C Sandrim
Oct 22, 2015·The Journal of Obstetrics and Gynaecology Research·Saeedeh SalimiAnoosh Naghavi
May 21, 2014·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Li-Li GongLi-Hong Liu
Oct 18, 2014·Archives of Gynecology and Obstetrics·Vanessa Resende Souza SilvaMarly Aparecida Spadotto Balarin
Feb 27, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Marcelo R LuizonJose E Tanus-Santos
May 29, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Lu ZhouChenhong Wang
Mar 31, 2017·Pharmacogenomics·Marcelo R LuizonValeria C Sandrim
Jun 14, 2017·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Semone ThakoordeenThajasvarie Naicker
Jul 21, 2017·International Journal of Molecular Sciences·Salvador Espino Y SosaGuadalupe Estrada-Gutierrez
Nov 7, 2018·Pharmacogenomics·Marcelo R LuizonJose E Tanus-Santos
Aug 31, 2018·Current Hypertension Reports·Semone ThakoordeenThajasvarie Naicker
Mar 16, 2018·Frontiers in Pharmacology·Marcelo R LuizonValeria C Sandrim
Jan 9, 2019·Frontiers in Physiology·Rafael Tomoya MichitaJosé Artur Bogo Chies

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