Complex traits such as human disease, growth rate, or crop yield are polygenic, or determined by the contributions from numerous genes in a quantitative manner. Although progress has been made in identifying major quantitative trait loci (QTL), experimental constraints have limited our knowledge of small-effect QTL, which may be responsible for a large proportion of trait variation. Here, we identified and dissected a one-centimorgan chromosome interval in Arabidopsis thaliana without regard to its effect on growth rate, and examined the signature of historical sequence polymorphism among Arabidopsis accessions. We found that the interval contained two growth rate QTL within 210 kilobases. Both QTL showed epistasis; that is, their phenotypic effects depended on the genetic background. This amount of complexity in such a small area suggests a highly polygenic architecture of quantitative variation, much more than previously documented. One QTL was limited to a single gene. The gene in question displayed a nucleotide signature indicative of balancing selection, and its phenotypic effects are reversed depending on genetic background. If this region typifies many complex trait loci, then non-neutral epistatic polymorphism may be an...Continue Reading
The tomato gene Pti1 encodes a serine/threonine kinase that is phosphorylated by Pto and is involved in the hypersensitive response
The Arabidopsis ERECTA gene encodes a putative receptor protein kinase with extracellular leucine-rich repeats
Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases
A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway
Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
A multilocus sequence survey in Arabidopsis thaliana reveals a genome-wide departure from a neutral model of DNA sequence polymorphism
QTL analysis for rice grain length and fine mapping of an identified QTL with stable and major effects
Inclusive composite interval mapping (ICIM) for digenic epistasis of quantitative traits in biparental populations
Genetic dissection and pyramiding of quantitative traits for panicle architecture by using chromosomal segment substitution lines in rice
hi2-1, a QTL which improves harvest index, earliness and alters metabolite accumulation of processing tomatoes.
'Good-genes' and 'compatible-genes' effects in an Alpine whitefish and the information content of breeding tubercles over the course of the spawning season
'Good-genes' and 'compatible-genes' effects in an Alpine whitefish and the information content of breeding tubercles over the course of the spawning season
Detection of epistatic interactions in association mapping populations: an example from tetraploid potato
Simultaneous fine mapping of closely linked epistatic quantitative trait loci using combined linkage disequilibrium and linkage with a general pedigree
Relationships between growth, growth response to nutrient supply, and ion content using a recombinant inbred line population in Arabidopsis
The gene controlling the indole glucosinolate modifier1 quantitative trait locus alters indole glucosinolate structures and aphid resistance in Arabidopsis
Identification of stably expressed quantitative trait loci for cooked rice elongation in non-Basmati varieties
Dynamic genetic linkage of intermediate blood pressure phenotypes during postural adaptations in a founder population
HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA forming microsatellite
Association of common variation in the PPARA gene with incident myocardial infarction in individuals with type 2 diabetes: a Go-DARTS study
Combining genome-wide association mapping and transcriptional networks to identify novel genes controlling glucosinolates in Arabidopsis thaliana
Mapping of QTL for resistance against the crucifer specialist herbivore Pieris brassicae in a new Arabidopsis inbred line population, Da(1)-12 x Ei-2
Genome-wide prediction of functional gene-gene interactions inferred from patterns of genetic differentiation in mice and men
Drought-adaptation potential in Fagus sylvatica: linking moisture availability with genetic diversity and dendrochronology
Epistatic interactions among herbicide resistances in Arabidopsis thaliana: the fitness cost of multiresistance
Epistasis for fitness-related quantitative traits in Arabidopsis thaliana grown in the field and in the greenhouse
Substitution mapping of dth1.1, a flowering-time quantitative trait locus (QTL) associated with transgressive variation in rice, reveals multiple sub-QTL
High-resolution quantitative trait locus mapping reveals sign epistasis controlling ovariole number between two Drosophila species
Development of a linkage map and mapping of phenotypic polymorphisms in a free-living population of Soay sheep (Ovis aries)
Selective sweeps reveal candidate genes for adaptation to drought and salt tolerance in common sunflower, Helianthus annuus
Flowering time quantitative trait Loci analysis of oilseed brassica in multiple environments and genomewide alignment with Arabidopsis
Nucleotide polymorphism and phenotypic associations within and around the phytochrome B2 Locus in European aspen (Populus tremula, Salicaceae)
Genetic expectations of quantitative trait loci main and interaction effects obtained with the triple testcross design and their relevance for the analysis of heterosis
Sequential elimination of major-effect contributors identifies additional quantitative trait loci conditioning high-temperature growth in yeast
Floral genetic architecture: an examination of QTL architecture underlying floral (co)variation across environments
High-resolution analysis of a QTL for resistance to Stagonospora nodorum glume blotch in wheat reveals presence of two distinct resistance loci in the target interval
Genetic variation in the cysteine biosynthesis pathway causes sensitivity to pharmacological compounds
Coregulation of host-response genes in integument: switchover of gene expression correlation pattern and impaired immune responses induced by dipteran parasite infection in the silkworm, Bombyx mori
Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair
Detection of epistatic interactions between exotic alleles introgressed from wild barley (H. vulgare ssp. spontaneum)
Heterosis for biomass-related traits in Arabidopsis investigated by quantitative trait loci analysis of the triple testcross design with recombinant inbred lines
Fitness effects associated with the major flowering time gene FRIGIDA in Arabidopsis thaliana in the field
Alleles versus mutations: Understanding the evolution of genetic architecture requires a molecular perspective on allelic origins
For others: epistasis and the evolutionary survival of an extreme tail of the quantitative distribution of autistic assets
Macroevolutionary patterns of glucosinolate defense and tests of defense-escalation and resource availability hypotheses
Functional and geographical differentiation of candidate balanced polymorphisms in Arabidopsis thaliana
Epistasis and the evolutionary dynamics of measured genotypic values during simulated serial bottlenecks
Analysis of segregation distortion and association of the bovine FGF2 with fertilization rate and early embryonic survival
Fitness differences associated with Pgi SNP genotypes in the Glanville fritillary butterfly (Melitaea cinxia)
Habitat-specific natural selection at a flowering-time QTL is a main driver of local adaptation in two wild barley populations
Tomato fruit ascorbic acid content is linked with monodehydroascorbate reductase activity and tolerance to chilling stress
Sequence diversity and haplotype associations with phenotypic responses to crowding: GIGANTEA affects fruit set in Arabidopsis thaliana
Distribution of genetic variation within and among local populations of Arabidopsis thaliana over its species range
Identification of metabolic and biomass QTL in Arabidopsis thaliana in a parallel analysis of RIL and IL populations
Diversification in flowering time due to tandem FT-like gene duplication, generating novel Mendelian factors in wild and cultivated rice
Rapid evolution of an adaptive cyanogenesis cline in introduced North American white clover (Trifolium repens L.)
The easy road to genome-wide medium density SNP screening in a non-model species: development and application of a 10 K SNP-chip for the house sparrow (Passer domesticus)
The genetic architecture of a complex ecological trait: host plant use in the specialist moth, Heliothis subflexa
Evolution of pleiotropy: epistatic interaction pattern supports a mechanistic model underlying variation in genotype-phenotype map
Dominant PRPF31 mutations are hypostatic to a recessive CNOT3 polymorphism in retinitis pigmentosa: a novel phenomenon of "linked trans-acting epistasis"
Genes underlying quantitative variation in ecologically important traits: PIF4 (phytochrome interacting factor 4) is associated with variation in internode length, flowering time, and fruit set in Arabidopsis thaliana
A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence
Genetic determinants and epistasis for life history trait differences in the common monkeyflower, Mimulus guttatus
Dearth of polymorphism associated with a sustained response to selection for flowering time in maize
Deeply diverged alleles in the Arabidopsis AREB1 transcription factor drive genome-wide differences in transcriptional response to the environment
Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking
Meta-analysis of metabolome QTLs in Arabidopsis: trying to estimate the network size controlling genetic variation of the metabolome
The Multi-allelic Genetic Architecture of a Variance-Heterogeneity Locus for Molybdenum Concentration in Leaves Acts as a Source of Unexplained Additive Genetic Variance
Accounting for genetic architecture improves sequence based genomic prediction for a Drosophila fitness trait
Modeling of a negative feedback mechanism explains antagonistic pleiotropy in reproduction in domesticated Caenorhabditis elegans strains
Epistasis × environment interactions among Arabidopsis thaliana glucosinolate genes impact complex traits and fitness in the field
Detecting epistasis with the marginal epistasis test in genetic mapping studies of quantitative traits
Genetic architecture of aerial and root traits in field-grown grafted grapevines is largely independent
Success and failure in replication of genotype-phenotype associations: How does replication help in understanding the genetic basis of phenotypic variation in outbred populations?
Modulation of ACD6 dependent hyperimmunity by natural alleles of an Arabidopsis thaliana NLR resistance gene
Comparison of the Relative Potential for Epigenetic and Genetic Variation To Contribute to Trait Stability
Naturally Segregating Variation at Ugt86Dd Contributes to Nicotine Resistance in Drosophila melanogaster
The contribution of cis- and trans-acting variants to gene regulation in wild and domesticated barley under cold stress and control conditions.
Interactions among genes involved in reverse cholesterol transport and in the response to environmental factors in dyslipidemia in subjects from the Xinjiang rural area
QTLs Associated with Agronomic Traits in the Cutler × AC Barrie Spring Wheat Mapping Population Using Single Nucleotide Polymorphic Markers
The role of population and quantitative genetics and modern sequencing technologies to understand evolved herbicide resistance and weed fitness
Mapping the genetic basis of symbiotic variation in legume-rhizobium interactions in Medicago truncatula
Theoretical model for gene-gene, gene-environment, and gene-sex interactions based on congenic-strain analysis of blood pressure in Dahl salt-sensitive rats
A quantitative trait locus on chromosome 4 affects cycling of hematopoietic stem and progenitor cells through regulation of TGF-beta 2 responsiveness
Artificial Selection Response due to Polygenic Adaptation from a Multilocus, Multiallelic Genetic Architecture
Multiple ancestral haplotypes harboring regulatory mutations cumulatively contribute to a QTL affecting chicken growth traits
QTL analysis of cotton fiber length in advanced backcross populations derived from a cross between Gossypium hirsutum and G. mustelinum
Fragmentation of two quantitative trait loci controlling collagen-induced arthritis reveals a new set of interacting subloci
Natural variation in Arabidopsis thaliana rosette area unveils new genes involved in plant development
Natural variation in the sequestosome-related gene, sqst-5, underlies zinc homeostasis in Caenorhabditis elegans.
Systematic identification of cis-regulatory variants that cause gene expression differences in a yeast cross.
Evolutionary population structure model reveals pleiotropic effects of GmPDAT for seed oil- and size-related traits in soybean
QTL.gCIMapping.GUI v2.0: An R software for detecting small-effect and linked QTLs for quantitative traits in bi-parental segregation populations
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Network quantitative trait loci mapping of circadian clock outputs identifies metabolic pathway-to-clock linkages in Arabidopsis
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