Dec 23, 2016

Epistasis and Entropy

PLoS Genetics
Kristina Crona

Abstract

Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large systems where systematic fitness measurements may not be possible. Some recent approaches depend on information theory. We show that considering shared entropy for pairs of loci can be misleading. The reason is that shared entropy does not imply epistasis for the pair. This observation holds true also in the absence of higher order epistasis. We discuss a method for reducing the number of false positives. However, our main conclusion is that entropy-based approaches have serious limitations in this context.

  • References8
  • Citations1

References

  • References8
  • Citations1

Citations

Mentioned in this Paper

Human Genetics
Adaptation
Entropy
Genetic Fitness
Information Theory
Deviation, Epistatic
Drug Resistance
Genetic Loci
Mutation Abnormality
Amino Acid Substitution

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