Epistasis and the mutation load: a measurement-theoretical approach.

Genetics
T F Hansen, G P Wagner

Abstract

An approximate solution for the mean fitness in mutation-selection balance with arbitrary order of epistatic interaction is derived. The solution is based on the assumptions of coupling equilibrium and that the interaction effects are multilinear. We find that the effect of m-order epistatic interactions (i.e., interactions among groups of m loci) on the load is dependent on the total genomic mutation rate, U, to the mth power. Thus, higher-order gene interactions are potentially important if U is large and the interaction density among loci is not too low. The solution suggests that synergistic epistasis will decrease the mutation load and that variation in epistatic effects will elevate the load. Both of these results, however, are strictly true only if they refer to epistatic interaction strengths measured in the optimal genotype. If gene interactions are measured at mutation-selection equilibrium, only synergistic interactions among even numbers of genes will reduce the load. Odd-ordered synergistic interactions will then elevate the load. There is no systematic relationship between variation in epistasis and load at equilibrium. We argue that empirical estimates of gene interaction must pay attention to the genetic backgro...Continue Reading

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Citations

Apr 6, 2005·Theoretical Population Biology·Uri Liberman, Marcus W Feldman
May 11, 2005·Journal of Theoretical Biology·Phil Hanlon, Andy Lorenz
Aug 27, 2005·Theoretical Population Biology·Ashley J R CarterThomas F Hansen
Jun 30, 2006·Trends in Genetics : TIG·Yoav GiladScott A Rifkin
May 22, 2007·Bio Systems·Marc Toussaint, Werner von Seelen
Dec 19, 2002·Evolution; International Journal of Organic Evolution·Adam H Porter, Norman A Johnson
Apr 10, 2004·Nature Genetics·Susanna K Remold, Richard E Lenski
Mar 13, 2001·Theoretical Population Biology·T F Hansen, G P Wagner
Jun 3, 2010·Genetics·Mihaela PavlicevThomas F Hansen
Oct 13, 2009·Evolution; International Journal of Organic Evolution·Janna L Fierst, Thomas F Hansen
Mar 17, 2015·Physics of Life Reviews·Lidan Sun, Rongling Wu

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