Epistasis and the release of genetic variation during long-term selection

Nature Genetics
Orjan CarlborgLeif Andersson

Abstract

It is an enigma how long-term selection in model organisms and agricultural species can lead to marked phenotypic changes without exhausting genetic variation for the selected trait. Here, we show that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci. The interactions in this radial network mediate a considerably larger selection response than predicted by a single-locus model.

References

Jan 1, 1992·Annual Review of Genetics·D S Falconer
Jun 7, 2002·Nature·Christine QueitschSusan Lindquist
Jun 24, 2003·The American Journal of Pathology·Mikiko Takikita-SuzukiRyuichi Kikkawa
Apr 3, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jonathan FlintNorman D Henderson
Jun 3, 2004·Current Opinion in Genetics & Development·Trudy F C Mackay
Jul 22, 2004·Nature Reviews. Genetics·Orjan Carlborg, Chris S Haley
Dec 14, 2004·Nature Genetics·Daniel SegrèRoy Kishony

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Citations

Nov 7, 2007·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Huihui LiJiankang Wang
Mar 31, 2011·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Tobias WürschumJochen Christoph Reif
Apr 9, 2011·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Jochen C ReifTobias Würschum
Jun 9, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zhoufei WangHongsheng Zhang
Oct 12, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Tobias WürschumJochen C Reif
Jun 16, 2011·Genetica·Nanye LongKent A Weigel
Oct 29, 2013·Trends in Genetics : TIG·Ronald M NelsonÖrjan Carlborg
Jan 10, 2013·Genetics Research·José M Álvarez-CastroÖrjan Carlborg
Oct 1, 2009·Heredity·W-H WeiD-J de Koning
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Liesbeth ZwartsTrudy F C Mackay
Aug 24, 2011·Genome Biology and Evolution·Lin XuZhenglong Gu
Oct 8, 2009·Human Molecular Genetics·Joseph H Nadeau
Jul 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Riikka KiveläHeikki Kainulainen
Aug 30, 2013·Proceedings. Biological Sciences·Etienne Rajon, Joshua B Plotkin
Sep 13, 2013·Genome Research·Maud RimbaultElaine A Ostrander
May 5, 2007·Annual Review of Genomics and Human Genetics·Michel Georges
May 30, 2013·Physiological Genomics·Lauren Gerard KochSteven L Britton
Jan 19, 2011·Genetics, Selection, Evolution : GSE·Francois BesnierOrjan Carlborg
Apr 30, 2013·BMC Evolutionary Biology·Watal M IwasakiMasakado Kawata
Jun 30, 2009·BMC Genetics·Lars RönnegårdOrjan Carlborg
Nov 16, 2007·BMC Biology·Arnaud Le RouzicOrjan Carlborg
Nov 17, 2010·PLoS Genetics·Anna M JohanssonOrjan Carlborg
Nov 30, 2011·PLoS Genetics·Patrick J BrownTorbert R Rocheford
Mar 20, 2013·PLoS Genetics·Gibran HemaniChris Haley
Sep 25, 2010·PloS One·Koen J F VerhoevenLauren M McIntyre

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