Epistasis of oxidative stress-related enzyme genes on modulating the risks in oral cavity cancer

Clinica Chimica Acta; International Journal of Clinical Chemistry
Szu-Hsien WuLi-Yu Tsai

Abstract

The aim of this study was to evaluate the risks of the polymorphisms of oxidant stress-related enzymes on patients with oral cavity cancer by genotyping of manganese superoxide dismutase (MnSOD [1183T>C]), myeloperoxidase (MPO [-463G>A]), catalase (CAT [-15A>T]) and glutathione peroxidases 1 (GPx1 [Pro198Leu]). A case-control study was conducted on 122 biopsy-proven oral cavity cancer patients with, at least, one of the past habits of cigarette smoking, alcohol drinking or betel-quid chewing, and 122 approximately age- and habit-matched controls. The independent risks of the polymorphisms for each enzyme on carcinogenicity were non-significant. The 2-order gene-gene interactions of the polymorphisms, assessed by using a logistic regression model, on risk did not show significant changes, neither. However, the epistasis, assessed by multifactor dimensionality reduction (MDR) for three-order (CAT, MnSOD, and MPO) and four-order was significant. Additionally, the fact that the levels of O(2)(-), GSSG and total GSH in the patients were significantly different according to certain genotypes which revealed that the polymorphisms of these enzymes could affect these parameters to some extent. The results suggested that the genetic-effe...Continue Reading

References

Nov 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y C KoC C Tsai
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·J S RosenblumR A Lerner
Dec 18, 2001·Free Radical Biology & Medicine·A I Cederbaum
Jul 11, 2002·Annals of Medicine·Jason H Moore, Scott M Williams
Oct 4, 2002·Nutrition·Yun-Zhong FangGuoyao Wu
May 13, 2003·International Journal of Cancer. Journal International Du Cancer·Ariana ZnaorPaolo Boffetta
Jul 17, 2003·The Tohoku Journal of Experimental Medicine·Ender InciGülden Burçax
Sep 3, 2004·Japanese Journal of Clinical Oncology·S Syed Sultan BeeviA Geetha
Jun 22, 2005·Acta Oto-laryngologica·Abdullah KalayciDogan Dolanmaz
Jan 3, 2006·The Journal of Allergy and Clinical Immunology·Iris H S ChanChristopher W K Lam
Sep 28, 2007·Human Heredity·Angeline S AndrewGiuseppe Matullo
Jul 2, 2009·Nutrition Reviews·Emilio HerreraCésar Fraga

❮ Previous
Next ❯

Citations

Aug 16, 2011·Journal of Cancer Research and Clinical Oncology·Jiawei ChenChangjun Yin
Jul 28, 2016·Journal of Cancer Research and Therapeutics·Jayendrakumar B PatelPrabhudas S Patel
Oct 18, 2012·Molecular Biology Reports·Zhiqiang HongXingliang Zhang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Risk Factors

Breast cancer is a multifactorial disease that is influenced by both environmental and genetic factors. Discover the latest research on the environmental and genetic risk factors for breast cancer here.