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Epistasis within the MHC contributes to the genetic architecture of celiac disease

bioRxiv

Feb 7, 2014

Ben GoudeyMichael T Inouye

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Abstract

Epistasis has long been thought to contribute to the genetic aetiology of complex diseases, yet few robust epistatic interactions in humans have been detected. We have conducted exhaustive genome-wide scans for pairwise epistasis in five independent celiac disease (CD) case-control stud...read more

Mentioned in this Paper

Premature Menopause
Study
Gene Mutant
Scanning
Single Nucleotide Polymorphism
Population Group
Genome
Virus Replication
PRRC2A gene
Major histocompatibility complex protein
28
19
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  • Epistasis within the MHC contributes to the genetic architecture of celiac disease

    bioRxiv

    Feb 7, 2014

    Ben GoudeyMichael T Inouye

    PMID: 990002485

    DOI: 10.1101/002485

    Abstract

    Epistasis has long been thought to contribute to the genetic aetiology of complex diseases, yet few robust epistatic interactions in humans have been detected. We have conducted exhaustive genome-wide scans for pairwise epistasis in five independent celiac disease (CD) case-control stud...read more

    Mentioned in this Paper

    Premature Menopause
    Study
    Gene Mutant
    Scanning
    Single Nucleotide Polymorphism
    28
    19

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