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Extensive epistasis within the MHC contributes to the genetic architecture of celiac disease

bioRxiv

Feb 7, 2014

Ben GoudeyMichael Inouye

Abstract

Epistasis has long been thought to contribute to the genetic aetiology of complex diseases, yet few robust epistatic interactions in humans have been detected. We have conducted exhaustive genome-wide scans for pairwise epistasis in five independent celiac disease (CeD) case-control stu...read more

Mentioned in this Paper

HLA Antigens
PRRC2A gene
GPANK1 gene
C6orf47 gene
Human Genetics
Lymphoma, Non-Hodgkin
Premature Menopause
Leukocyte Mediated Immunity
ELMO protein, Drosophila
Major histocompatibility complex protein
28
19
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Extensive epistasis within the MHC contributes to the genetic architecture of celiac disease

bioRxiv

Feb 7, 2014

Ben GoudeyMichael Inouye

PMID: 990002485

DOI: 10.1101/002485

Abstract

Epistasis has long been thought to contribute to the genetic aetiology of complex diseases, yet few robust epistatic interactions in humans have been detected. We have conducted exhaustive genome-wide scans for pairwise epistasis in five independent celiac disease (CeD) case-control stu...read more

Mentioned in this Paper

HLA Antigens
PRRC2A gene
GPANK1 gene
C6orf47 gene
Human Genetics
Lymphoma, Non-Hodgkin
Premature Menopause
Leukocyte Mediated Immunity
ELMO protein, Drosophila
Major histocompatibility complex protein
28
19

Similar Papers Found In These Feeds

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