Epistatic and pleiotropic effects of polymorphisms in the fibrinogen and coagulation factor XIII genes on plasma fibrinogen concentration, fibrin gel structure and risk of myocardial infarction

Thrombosis and Haemostasis
Maria Nastase MannilaAngela Silveira

Abstract

An intricate interplay between the genes encoding fibrinogen gamma (FGG), alpha (FGA) and beta (FGB), coagulation factor XIII (F13A1) and interleukin 6 (IL6) and environmental factors is likely to influence plasma fibrinogen concentration, fibrin clot structure and risk of myocardial infarction (MI). In the present study, the potential contribution of SNPs harboured in the fibrinogen, IL6 and F13A1 genes to these biochemical and clinical phenotypes was examined. A database and biobank based on 387 survivors of a first MI and population-based controls were used. Sixty controls were selected according to FGG 9340T > C [rs1049636] genotype for studies on fibrin clot structure using the liquid permeation method. The multifactor dimensionality reduction method was used for interaction analyses. We here report that the FGA 2224G > A [rs2070011] SNP (9.2%), plasma fibrinogen concentration (13.1%) and age (8.1%) appeared as independent determinants of fibrin gel porosity. The FGA 2224G > A SNP modulated the relation between plasma fibrinogen concentration and fibrin clot porosity. The FGG-FGA*4 haplotype, composed of the minor FGG 9340C and FGA 2224A alleles, had similar effects, supporting its reported protective role in relation to M...Continue Reading

Citations

Feb 20, 2010·BMC Medical Genetics·Eirini V TheodorakiGeorge V Dedoussis
Dec 2, 2008·Omics : a Journal of Integrative Biology·Beverly McCabe-SellersJim Kaput
Jul 30, 2011·Thrombosis and Haemostasis·Johanne SilvainJean-Phillippe Collet
Mar 6, 2012·European Journal of Epidemiology·Gie Ken-DrorFotios Drenos
Jan 13, 2009·American Journal of Respiratory and Critical Care Medicine·Annette PetersUNKNOWN AIRGENE Study Group
Sep 18, 2013·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Fei ChenZaoping Chen
Aug 27, 2014·British Journal of Haematology·Retha C KotzéMarlien Pieters
Jul 28, 2006·International Journal of Epidemiology·Tom W MeadeBianca L De Stavola

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