Epistatic and synergistic interactions between circadian clock mutations in Neurospora crassa.

Genetics
L W Morgan, J F Feldman

Abstract

We identified a series of epistatic and synergistic interactions among the circadian clock mutations of Neurospora crassa that indicate possible physical interactions among the various clock components encoded by these genes. The period-6 (prd-6) mutation, a short-period temperature-sensitive clock mutation, is epistatic to both the prd-2 and prd-3 mutations. The prd-2 and prd-3 long-period mutations show a synergistic interaction in that the period length of the double mutant strain is considerably longer than predicted. In addition, the prd-2 prd-3 double mutant strain also exhibits overcompensation to changes in ambient temperature, suggesting a role in the temperature compensation machinery of the clock. The prd-2, prd-3, and prd-6 mutations also show significant interactions with the frq(7) long-period mutation. These results suggest that the gene products of prd-2, prd-3, and prd-6 play an important role in both the timing and temperature compensation mechanisms of the circadian clock and may interact with the FRQ protein.

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Citations

Jan 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Christian I HongJohn J Tyson
Oct 19, 2004·Annual Review of Microbiology·Patricia L Lakin-Thomas, Stuart Brody
Nov 17, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·L W MorganD Bell-Pedersen
Mar 30, 2010·Journal of Biological Rhythms·Sanshu Li, Patricia Lakin-Thomas
Mar 8, 2011·Journal of Evolutionary Biology·R DharA Wagner

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