Epistemology in the intensive care unit-what is the purpose of a definition? : Paradigm shift in sepsis research

Der Anaesthesist
P DickmannM Bauer

Abstract

The adoption of the new sepsis definition in early 2016 introduced a new paradigm for the clinical picture of sepsis. Up until now, sepsis was defined as a systemic inflammatory reaction (systemic inflammatory response syndrome, SIRS) to an infection. Based on a better understanding of the molecular mechanisms, the focus of the new definition is no longer the inflammatory response, but rather the tissue damage and impairment of organ function which this induces. The paradigm thus moves away from the infection and the systemic inflammatory response, and toward that which makes sepsis so dangerous in terms of both disease dynamics and outcome: organ failure due to a dysregulated host response to an infection. This change of perspective or paradigm enables patients with an increased risk of developing sepsis to be recognized and treated earlier in clinical routine, even outside of the intensive care unit. The new definition also promotes development of new treatment strategies with improved ability to treat sepsis causally.

References

Feb 24, 2016·JAMA : the Journal of the American Medical Association·Christopher W SeymourDerek C Angus
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Manu Shankar-HariUNKNOWN Sepsis Definitions Task Force
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Jul 5, 2016·Chest·Poushali BhattacharjeeMatthew M Churpek
Jan 24, 2017·JAMA : the Journal of the American Medical Association·Eamon P RaithUNKNOWN Australian and New Zealand Intensive Care Society (ANZICS) Centre for Outcomes and Resource Evaluation (CORE)
Jan 24, 2017·JAMA : the Journal of the American Medical Association·Yonathan FreundUNKNOWN French Society of Emergency Medicine Collaborators Group

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Citations

Jan 11, 2019·Journal of Clinical Medicine·Ronson S L LoColin A Graham
Apr 3, 2020·Der Urologe. Ausg. A·B Ternes, F M E Wagenlehner
Apr 6, 2019·Frontiers in Immunology·Ebru KarasuMarkus Huber-Lang

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