Epithelial cell contributions to intestinal immunity

Advances in Immunology
Lora V Hooper

Abstract

The epithelial surfaces of the mammalian intestine interface directly with the external environment and thus continuously encounter pathogenic bacteria, fungi, viruses, and parasites. The intestinal epithelium is also closely associated with complex communities of symbiotic microorganisms. Intestinal epithelial cells are thus faced with the unique challenge of directly interacting with enormous numbers of microbes that include both pathogens and symbionts. As a result, gut epithelia have evolved an array of strategies that contribute to host immunity. This chapter considers the various mechanisms used by epithelial cells to limit microbial invasion of host tissues, shape the composition of indigenous microbial communities, and coordinate the adaptive immune response to microorganisms. Study of intestinal epithelial cells has contributed fundamental insights into intestinal immune homeostasis and has revealed how impaired epithelial cell function can contribute to inflammatory disease.

Citations

Jan 7, 2016·Frontiers in Veterinary Science·Lonneke OnrustFilip Van Immerseel
Apr 23, 2017·The Journal of Experimental Medicine·Ana M C FariaDaniel Mucida
Mar 8, 2016·Inflammatory Bowel Diseases·Stewart S Cao
Mar 13, 2018·Journal of Crohn's & Colitis·Ole Haagen NielsenAlan C Moss
Nov 22, 2017·Autophagy·Elizabeth Delorme-Axford, Daniel J Klionsky
Aug 3, 2018·Nature Reviews. Gastroenterology & Hepatology·Keith A SharkeyDerek M McKay
Dec 6, 2017·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Samantha N FreedmanAshutosh K Mangalam
Jun 23, 2018·The Journal of Experimental Medicine·Michael G KattahAveril Ma
Apr 21, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Fergus Shanahan, Donal Sheehan
Mar 30, 2017·Frontiers in Immunology·Johanna Pott, Silvia Stockinger
Apr 7, 2019·Mucosal Immunology·Mei Lan ChenMark S Sundrud
Mar 14, 2020·Nature Communications·Sabrina JabsPascale Cossart
Aug 5, 2020·Journal of Dairy Science·C Kent-DennisG B Penner
Nov 9, 2019·Cell Death & Disease·Lester ThooPhilippe Krebs
Mar 16, 2019·Scientific Reports·Keena S ThomasJames E Casanova
Oct 6, 2017·Archives of Virology·Mahmoud Mohammad YaseenBarakat Mohammad Shabsoug
Apr 22, 2020·International Journal of Colorectal Disease·Vladana DomazetovicMaria Stio
Jan 8, 2021·Cells·Rashmita PradhanRocío López-Posadas
Apr 14, 2021·Proceedings of the National Academy of Sciences of the United States of America·Pilar Samperio VentayolMikael E Sellin
May 1, 2021·International Journal of Molecular Sciences·Edoardo TronconeGiovanni Monteleone
May 1, 2021·International Journal of Molecular Sciences·Daria AugustyniakFionnuala T Lundy
Jul 15, 2021·Animal Nutrition·Jie PengYanhua Huang
Jun 26, 2021·Advanced Healthcare Materials·Christina Cortez-JugoFrank Caruso
Sep 29, 2021·Molecular Pharmaceutics·Fengjiao LiZhonghua Liu

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