Epithelial cell heterogeneity in mammalian thymus: monoclonal antibody to high molecular weight keratins exclusively binds to Hassall's corpuscles.

The Histochemical Journal
J F NicolasJ Thivolet

Abstract

Hassall's corpuscles represent a subset of medullary thymic epithelial cells whose origin and function within the thymus still remain largely unknown. The present study shows that Hassall's corpuscles can be defined by their intracellular content in specific keratin subunits. Two monoclonal anti-keratin antibodies were used: KL1, directed to high molecular weight keratins, and KL4, specific for high and medium molecular weight polypeptides. In vivo, KL1 exclusively binds to Hassall's corpuscles of five mammalian species including mouse, rat, guinea-pig, rabbit and pig. Thus KL1 appears as an exclusive marker of Hassall's corpuscles in a large number of mammals. In vitro, thymic epithelial cells gave rise in certain species to Hassall's corpuscles. In contrast to its in vivo reactivity, KL1 never labelled Hassall's corpuscles developed in vitro. These data strongly support the following conclusions: (1) Hassall's corpuscles derive from medullary epithelial cells; (2) they represent advanced stages of thymic epithelial maturation; (3) thymic epithelial cell differentiation is impaired in vitro. Furthermore, this study provides additional evidence that thymic epithelium heterogeneity reflects different stages in epithelial maturat...Continue Reading

References

Jul 30, 1976·Cell and Tissue Research·J M Scheiff
Jul 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J F NicolasM Dardenne
May 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M HaftekJ Thivolet
Jan 1, 1988·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·D P WirtJ M Layton
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K H SingerB F Haynes
Jul 1, 1985·The Journal of Investigative Dermatology·K H SingerB F Haynes
Jan 1, 1968·Zeitschrift für Zellforschung und mikroskopische Anatomie·T Mandel
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·T Mandel
Jan 1, 1980·Archives of Dermatological Research·J ViacC Goujon
Jul 1, 1983·The Journal of Investigative Dermatology·T T SunJ Woodcock-Mitchell
Oct 1, 1983·The Journal of Investigative Dermatology·J ViacJ Thivolet
Jan 1, 1980·American Journal of Industrial Medicine·T J SmithJ C Reading
Jan 1, 1963·The American Journal of Anatomy·S L CLARK

❮ Previous
Next ❯

Citations

Jan 1, 1995·Cell and Tissue Research·E ShezenO Abramsky
Jun 8, 2000·Forensic Science International : Synergy·H NishioK Suzuki
Jun 7, 2002·Journal of Virology·Pierre-Olivier VidalainHélène Valentin
Jan 1, 2012·International Journal of Applied & Basic Medical Research·Adil AsgharFaruqi A Nafis
Mar 11, 2017·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Renáta MikušováIvan Varga
Aug 1, 1997·Microscopy Research and Technique·E J De Waal, L H Rademakers
Nov 25, 2003·Microscopy Research and Technique·Renata Brelińska
Nov 30, 2000·The Veterinary Record·A BlancoA Méndez
Aug 28, 2020·Immunological Reviews·Mia Hamilton JeeCharlotte Menné Bonefeld

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.