PMID: 9527213Apr 4, 1998Paper

Epithelial cell hyperproliferation after biliopancreatic reflux into the esophagus of rats

The Annals of Thoracic Surgery
M PeraV F Trastek

Abstract

Chronic reflux of duodenal contents into the esophagus of rats produces severe esophagitis and exerts a co-carcinogenic effect on the proliferating cells by enhancing the formation of nitrosamine-induced esophageal carcinomas. We investigated the effect of the different components of the duodenal reflux on the epithelial cell proliferation of the lower esophagus. Sprague-Dawley rats underwent three surgical reflux models (biliopancreatic, pancreatic, and biliary) and a sham operation. Animals were sacrificed at 72 hours, 6 weeks, and 9 weeks after the operation. Histology and cell proliferation, determined by ornithine decarboxylase activity, polyamine (putrescine, spermidine, spermine) levels, and proliferating cell nuclear antigen labeling index of the basal and suprabasal layers, were studied in the distal esophagus. Both biliopancreatic and pancreatic reflux induced severe esophagitis starting on week 6. Suprabasal proliferating cell nuclear antigen labeling index significantly increased throughout the 9 weeks of the study in the biliopancreatic and pancreatic reflux groups, although this increase was earlier in the former group. Ornithine decarboxylase activity and polyamine levels were significantly increased in the bilio...Continue Reading

Citations

Jun 1, 2005·The Journal of Surgical Research·Yan LiRobert C G Martin
Feb 21, 2006·Minerva gastroenterologica e dietologica·V LunedeiE Roda
Mar 21, 2002·Chest Surgery Clinics of North America·Alan G Casson
Jan 13, 2000·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S J WalkerN Birbeck
Dec 11, 2002·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Y Koak, M Winslet
Apr 13, 2004·Journal of Pediatric Gastroenterology and Nutrition·Yvone VicenteJuan A Tovar
Feb 3, 2007·Alimentary Pharmacology & Therapeutics·S J CraneN J Talley
Apr 21, 2007·Pediatrics International : Official Journal of the Japan Pediatric Society·Rok Orel, Gaj Vidmar
Nov 23, 2005·Acta Cirúrgica Brasileira·Edmilson Vieira Gaia FilhoHenrique Oliveira Costa
Jul 24, 2002·Gastroenterology Clinics of North America·David A Katzka
Apr 27, 2007·The American Journal of Gastroenterology·Sarah J CraneNicholas J Talley
Dec 23, 2011·The Journal of Veterinary Medical Science·Kankanam Gamage Sanath UdayangaHiroshi Kitagawa
Nov 24, 1999·Scandinavian Journal of Gastroenterology·N OmuraT Aoki

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