Epithelial cell in intestinal homeostasis and inflammatory bowel diseases

Médecine sciences : M/S
Lilia Zouiten-MekkiAzza Filali

Abstract

Crohn's disease (CD) and ulcerative colitis (UC) are the principal inflammatory bowel diseases (IBD) which physiopathology is currently poorly elucidated. During these diseases, the participation of the epithelial cell in the installation and the perpetuation of the intestinal inflammation is now clearly implicated. In fact, the intestinal epithelium located at the interface between the internal environment and the intestinal luminal, is key to the homeostatic regulation of the intestinal barrier. This barrier can schematically be regarded as being three barriers in one: a physical, chemical and immune barrier. The barrier function of epithelial cell can be altered by various mechanisms as occurs in IBD. The goal of this article is to review the literature on the role of the epithelial cell in intestinal homeostasis and its implication in the IBD.

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Citations

Dec 18, 2015·Médecine sciences : M/S·Jean-Luc DesseynFrédéric Gottrand
Jul 15, 2015·Médecine sciences : M/S·Anne-Gaelle Le LouppDamien Masson
Aug 22, 2021·Cellular and Molecular Gastroenterology and Hepatology·Varsha SinghYan Rong

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