PMID: 37647May 4, 1979

Epithelial cell kinetics in the descending colon of the rat

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
R P RijkeN J Langendoen

Abstract

Epithelial cell kinetics were investigated in the descending colon of the rat. The number of cells per crypt was found to be approximately 625, with 33 cells per cell column and 19 cell columns per crypt circumference. The growth fraction of the colonic crypt was 0.42, and proliferating cells were situated largely in the lower half of the crypt. The cell cycle time was 50.5 h, with values for the G1, S and G2 phases of 40.0, 7.6 and 2.9 h respectively. Cell migration studies showed that it took 60-72 h for a cell to migrate from the upper border of the proliferative cell compartment in the crypt to the luminal surface of the colon. Data were also obtained from continuous labelling with tritiated thymidine and from studying the circadian rhythm of proliferative activity, which suggest that the cells in the bottom of the crypt may constitute a separate, more slowly cycling (stem)cell compartment.

References

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Citations

Jan 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R P Rijke, R Gart
Jan 1, 1977·Cell and Tissue Kinetics·R F Hagemann, J J Stragand
Mar 1, 1975·Cell and Tissue Kinetics·A B Cairnie, B H Millen
Dec 1, 1972·Clinical Science·M H GleesonR H Dowling
May 1, 1974·Diseases of the Colon and Rectum·C ChomchaiN D Nigro

Related Concepts

Taenia Coli
Thymidine
Interphase
Cell Motility
Benign Neoplasm of Descending Colon
Compartment of Cell
Structure of Intestinal Gland
Circadian Rhythm Pathway Kegg
Cell Density
Cell Cycle

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