PMID: 42196Jan 1, 1979

Epithelial cell kinetics in the descending colon of the rat. I. The effect of ischaemia-induced epithelial cell loss

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
R P Rijke, R Gart

Abstract

Epithelial cell loss was induced in the descending colon of the rat by temporary ischaemia to investigate whether this would lead to an increase in crypt cell proliferation. Shortly after the temporary ischaemia the number of cells per crypt was markedly reduced, and it was shown that the cell loss occurred mainly from the non-proliferating upper half of the crypt. The number of cells per crypt reached control values again after 24-48 h. There was a marked increase in proliferative activity, as reflected by the labelling index after 3HTdR and by the mitotic index, with peak values at 16 and 24 h after ischaemia. After 48 h the proliferative indices were normal again. The increase in crypt cell proliferation was characterized by an increase in the labelling index as well as in the mitotic index per crypt cell position. No enlargement of the proliferative cell compartment in the crypt was observed. It is most likely then that the increase in crypt cell proliferation was brought about by a shortening of the cell cycle, since the growth fraction in the lower half of the crypt approaches 1.0. The possible implications of the present data for the control of colonic cell proliferation and colonic carcinogenesis are discussed.

References

May 1, 1993·Diseases of the Colon and Rectum·J L McCue, R K Phillips
Jan 1, 1983·Comparative Biochemistry and Physiology. A, Comparative Physiology·T Sakata, W von Engelhardt
Jun 1, 1981·Gut·J W RobinsonF Saegesser
May 4, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R P RijkeN J Langendoen
Jan 1, 1984·Pediatric Radiology·D F MertenJ C Leonidas
Dec 24, 1997·Journal of Pineal Research·B D Callaghan
May 1, 1986·The Australian and New Zealand Journal of Surgery·W D FordB S Douglas
Mar 1, 2017·PLoS Computational Biology·Sophie K KayHelen M Byrne
Jan 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R P RijkeN J Langendoen

Citations

May 4, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R P RijkeN J Langendoen
Jan 1, 1977·Cell and Tissue Kinetics·R F Hagemann, J J Stragand
Jun 1, 1977·The American Journal of Clinical Nutrition·J J Stragand, R F Hagemann
Feb 1, 1975·Cancer·E E Deschner, M Lipkin
Mar 1, 1975·Cell and Tissue Kinetics·A B Cairnie, B H Millen
Jul 14, 1975·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·J W RobinsonV Mirkovitch
Oct 1, 1973·Physiological Reviews·M Lipkin

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