PMID: 42197Jan 1, 1979

Epithelial cell kinetics in the descending colon of the rat. II. The effect of experimental bypass

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
R P RijkeN J Langendoen

Abstract

The influence of experimental bypass on the epithelial cell kinetics in the rat descending colon was studied. It was found that the number of cells per crypt was markedly reduced at 6 weeks after bypass. The percentage of labelled crypt cells, 1 h after 3HTdR, and the distribution of labelled cells in the crypt was normal. Also the life span of the epithelial cells was the same in control and bypassed colon. The response of crypt cell proliferation to ischaemia-induced cell loss in the bypassed descending colon was similar to the one previously described for normal descending colon. This indicates that the absence of the normal luminal contents does not result in a different response of colonic crypts to induced cell loss. Furthermore, it was found that the number of cells per crypt and the proliferative activity did not change in the transverse colon after temporary ischaemia of the bypassed descending colon. This indicates that the increase in crypt cell proliferation after ischaemia-induced cell loss is a local response.

References

Apr 1, 1990·Digestive Diseases and Sciences·L DeruyterG Willems
Dec 1, 1984·Journal of Surgical Oncology·C A RubioA Duvander
Jul 16, 2008·Physiological Reviews·Dirk Heitzmann, Richard Warth
Jan 1, 1984·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·P BlomquistB Zederfeldt
Dec 1, 1988·Scandinavian Journal of Gastroenterology·T Sakata

Citations

Jan 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R P Rijke, R Gart
Jun 1, 1977·The American Journal of Clinical Nutrition·J J Stragand, R F Hagemann
Oct 1, 1973·Physiological Reviews·M Lipkin
Dec 1, 1972·Clinical Science·M H GleesonR H Dowling
Jun 1, 1973·Journal of the National Cancer Institute·B S Reddy, E L Wynder
May 1, 1974·Diseases of the Colon and Rectum·C ChomchaiN D Nigro

Related Concepts

Structure of Intestinal Gland
Taenia Coli
Autoradiography
Cell Division Phases

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