Epithelial cell proliferation of the colonic mucosa in different degrees of colonic diverticular disease

Journal of Clinical Gastroenterology
Antonio TursiFabio Aiello

Abstract

This study assesses the epithelial cell proliferation in different degrees of diverticular disease and compares this with two different control groups. Hyperproliferation of the colonic mucosa has been recently described in diverticular disease (DD), but it is unknown whether this finding is present in every degree of DD. Thirty consecutive patients with a new endoscopic diagnosis of DD (10 with asymptomatic diverticulosis, 10 with symptomatic uncomplicated DD, and 10 with acute uncomplicated diverticulitis) were enrolled. Ten matched healthy people and 10 patients with ulcerative colitis (UC) (5 with UC in remission and 5 with active UC) were enrolled as control groups. The Ki-67 antigen index of the whole crypt and the upper third was separately evaluated. Ki-67 index of the whole crypt and the upper third of the crypt was significantly higher in all degrees of DD compared with the healthy control group. In particular, asymptomatic diverticulosis showed a threefold higher Ki-67 index compared with that of the healthy control group (5.4% and 5.6% vs. 1.6% and 1.8%, respectively, P = 0.005), and similar to that of UC in remission (5.4% and 5.6% vs. 5.9% and 5.8%, respectively, P = not significant). We found an upward shifting o...Continue Reading

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Citations

Jul 3, 2008·International Journal of Colorectal Disease·M M Meurs-SzojdaR J F Felt-Bersma
Jul 7, 2009·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·T J LamR J F Felt-Bersma
Feb 6, 2010·World Journal of Gastrointestinal Pharmacology and Therapeutics·Antonio Tursi
May 29, 2014·International Journal of Colorectal Disease·Adnan MuhammadGitanjali Vidyarthi
Jan 31, 2008·Digestive Diseases and Sciences·Antonio TursiFabio Aiello
Apr 5, 2008·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·A TursiF Aiello
Jun 25, 2009·Alimentary Pharmacology & Therapeutics·A Tursi, S Papagrigoriadis
Jul 28, 2016·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Veeravich JaruvongvanichSikarin Upala
May 31, 2018·Expert Review of Gastroenterology & Hepatology·Kathleen M SchiefferWalter A Koltun
May 21, 2010·Journal of Clinical Gastroenterology·Antonio TursiFabio Aiello
Jan 8, 2008·Alimentary Pharmacology & Therapeutics·M M SzojdaR J F Felt-Bersma
Apr 13, 2012·Journal of Clinical Gastroenterology·Antonio Tursi
Jun 27, 2008·Journal of Clinical Gastroenterology·Sergio MoriniSalvatore M A Campo
Sep 14, 2016·Journal of Clinical Gastroenterology·Giuseppe GrandeRita L Conigliaro
Jun 3, 2020·European Journal of Gastroenterology & Hepatology·Antonio TursiFrancesco Di Mario
Jun 27, 2019·Gastroenterology Research and Practice·Yeon-Ji KimJi Min Lee
Jan 29, 2021·Medicina·Angelo ViscidoGiovanni Latella

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