Epithelial cell responses to infection with human papillomavirus.

Clinical Microbiology Reviews
Margaret A Stanley

Abstract

Human papillomavirus (HPV) infection of the genital tract is common in young sexually active individuals, the majority of whom clear the infection without overt clinical disease. Most of those who do develop benign lesions eventually mount an effective cell-mediated immune (CMI) response, and the lesions regress. Regression of anogenital warts is accompanied histologically by a CD4(+) T cell-dominated Th1 response; animal models support this and provide evidence that the response is modulated by antigen-specific CD4(+) T cell-dependent mechanisms. Failure to develop an effective CMI response to clear or control infection results in persistent infection and, in the case of the oncogenic HPVs, an increased probability of progression to high-grade intraepithelial neoplasia and invasive carcinoma. Effective evasion of innate immune recognition seems to be the hallmark of HPV infections. The viral infectious cycle is exclusively intraepithelial: there is no viremia and no virus-induced cytolysis or cell death, and viral replication and release are not associated with inflammation. HPV globally downregulates the innate immune signaling pathways in the infected keratinocyte. Proinflammatory cytokines, particularly the type I interfero...Continue Reading

References

Jan 1, 1991·Dermatologica·M K ReuschV B Morhenn
Oct 1, 1981·Gynecologic Oncology·H zur HausenL Gissmann
Dec 1, 1994·American Journal of Clinical Pathology·N ColemanM A Stanley
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·J A SuzichR Schlegel
Nov 1, 1996·The Journal of Infectious Diseases·J J CarterD A Galloway
Nov 18, 1997·Cell·R Medzhitov, C A Janeway
Mar 13, 2002·Cancer Letters·Soo-Jong UmJong-Sup Park
Jun 29, 2002·Current Opinion in Immunology·Agnes Le Bon, David F Tough
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Steven C FauschW Martin Kast
Dec 5, 2002·Clinical and Experimental Dermatology·M A Stanley
Jan 16, 2003·Immunology Letters·Shizuo Akira, Hiroaki Hemmi
Aug 6, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rongcun YangRichard B S Roden
Mar 9, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·John Doorbar
Oct 13, 2005·Vaccine·Margaret Stanley
Mar 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Mark R PettNicholas Coleman
Sep 5, 2006·Virology·Suchitra JainMargaret A Stanley
Sep 5, 2006·Vaccine·D Maxwell Parkin, Freddie Bray
Sep 5, 2006·Vaccine·Anna-Barbara MoscickiLuisa L Villa
Jan 18, 2007·The Journal of Investigative Dermatology·Lloyd S Miller, Robert L Modlin
Feb 20, 2007·Current Cancer Drug Targets·Shreya KanodiaW Martin Kast
May 15, 2007·The New England Journal of Medicine·Suzanne M GarlandUNKNOWN Females United to Unilaterally Reduce Endo/Ectocervical Disease (FUTURE) I Investigators
May 17, 2007·European Journal of Immunology·Antony P B BlackGraham S Ogg
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Diane M Da SilvaW Martin Kast
Jul 14, 2007·Disease Markers·John Doorbar
Nov 1, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Simon R MyersHarshad Navsaria
Jan 4, 2008·Cancer Research·Svetlana VinokurovaMagnus von Knebel Doeberitz

❮ Previous
Next ❯

Citations

Jun 15, 2013·Archives of Dermatological Research·M ReinholzJ Schauber
Jan 16, 2013·The Journal of Infectious Diseases·Lea WiddiceAnna-Barbara Moscicki
Sep 13, 2013·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K KeroS Syrjänen
Feb 11, 2014·Medical Microbiology and Immunology·Fabiana CannellaAlessandra Pierangeli
Jul 19, 2014·Indian Journal of Dermatology, Venereology and Leprology·Jose M Rios-YuilIvan Rubio-Gayosso
Sep 3, 2014·Pathology Research International·Anthonio AdefuyeKurt Jason Sales
Jul 3, 2013·Current Opinion in Virology·John Doorbar
Jun 27, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Irena Hočevar-BoltežarMiha Zargi
Jun 20, 2013·Expert Opinion on Medical Diagnostics·Rogier J N T M LitjensArnold-Jan Kruse
Dec 3, 2014·Experimental Eye Research·Stephen GichuhiMatthew J Burton
Dec 27, 2015·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Janaina CoserVagner Ricardo Lunge
Dec 15, 2015·Papillomavirus Research·Diane M Da SilvaW Martin Kast
Dec 5, 2012·Vaccine·John DoorbarMargaret A Stanley
Feb 13, 2016·Journal of Cancer Therapy·Chrispin ChisangaPeter C Angeletti
Sep 12, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Diane M Da SilvaW Martin Kast
Mar 8, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P V Chin-HongUNKNOWN AST Infectious Diseases Community of Practice
Mar 11, 2015·Reviews in Medical Virology·John DoorbarIsao Murakami
Jun 22, 2013·International Journal of Dermatology·Matilde Iorizzo, Gionata Marazza
Oct 19, 2013·International Journal of Cancer. Journal International Du Cancer·Jennifer Pahne-ZeppenfeldSigrun Smola
Apr 26, 2016·Infectious Diseases in Obstetrics and Gynecology·Lea Maria Margareta AmbühlSuzette Sørensen
Nov 1, 2015·Journal of Medical Virology·Hai Ha Long LeHiroshi Ichimura
Apr 12, 2016·Cytokine·Jennifer O LamGypsyamber D'Souza
Jan 21, 2014·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Alfred BereJo-Ann S Passmore
Oct 31, 2014·Journal of Virology·Cody J WarrenDohun Pyeon
Aug 14, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F AnjuèreC Luci
Mar 15, 2015·PLoS Computational Biology·Marc D RyserRick Durrett
Jul 9, 2016·Human Vaccines & Immunotherapeutics·Nicolas Çuburu, John T Schiller
Jul 16, 2016·PloS One·Gabriela A Martínez-NavaKirvis Torres-Poveda
Aug 2, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Maria KyrgiouAnna-Barbara Moscicki
Sep 27, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Liam MastersonJane Sterling
Mar 8, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Alaa MosbahGhada Barakat
Jan 25, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J A Fishman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.