PMID: 16505599Mar 1, 2006Paper

Epithelial cells as sentinels in mucosal immune barrier

Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology
Koji Hase, Hiroshi Ohno

Abstract

The mucosal surface of the body is exposed to a vast array of exogenous antigens and microorganisms. Epithelial cells evoke minimal immune response to food ingredients and commensal bacteria, while they release an array of antimicrobial peptides and CXC chemokines in response to bacterial invasion or inflammatory stimuli. The mucosal antigens are transported from the gut lumen to organized lymphoid follicles by specialized epithelial M cells residing in follicle-associated epithelium (FAE). An alternative pathway of antigen uptake with neonatal Fc receptor (FcRn) is also reported. Furthermore, intestinal dendritic cells underneath epithelium directly take up luminal antigens, where epithelial fractalkine expression plays a critical role in the guidance of dendrite extrusion. Epithelial cells express polymeric Ig receptor (pIgR) that is essential for the luminal secretion of dimeric IgA produced in the lamina propria. Furthermore, soluble factors released by mucosal epithelial cells condition dendritic cells, which in turn promote Th2 response. These multiple lines of evidence clearly suggest the significant role of epithelial cells at the front line of mucosal immune defense.

References

Jul 9, 1992·Nature·A ZychlinskyP J Sansonetti
May 1, 1971·The Histochemical Journal·Y Ghoos, G Vantrappen
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·D M MonackS Falkow
Nov 14, 1997·The American Journal of Physiology·S D SavkovicG Hecht
Oct 21, 1998·Trends in Microbiology·M A Jepson, M A Clark
Nov 20, 1998·The Journal of Clinical Investigation·J M KimM F Kagnoff
May 18, 1999·The Journal of Biological Chemistry·N InoharaG Núñez
Oct 14, 2000·Annual Review of Cell and Developmental Biology·D L GoosneyB B Finlay
Oct 14, 2000·Annual Review of Cell and Developmental Biology·J P Kraehenbuhl, M R Neutra
Nov 22, 2000·The Journal of Biological Chemistry·J HarderJ M Schroder
Apr 3, 2001·Nature Reviews. Molecular Cell Biology·S TsukitaM Itoh
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M ColeR M Strieter
Jul 21, 2001·EMBO Reports·S E GirardinD J Philpott
Aug 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A T GewirtzJ L Madara
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·F SierroJ C Sirard
Jan 24, 2002·The Journal of Experimental Medicine·Edward P BowmanEugene C Butcher
Feb 5, 2002·Immunity·Eric J Kunkel, Eugene C Butcher
Mar 6, 2002·The Journal of Experimental Medicine·Mathias W HornefAgneta Richter-Dahlfors
Mar 26, 2002·Trends in Microbiology·Daniela Büttner, Ulla Bonas
May 22, 2002·Nature Immunology·Dipankar GhoshCharles L Bevins

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Citations

Feb 19, 2010·Animal Science Journal = Nihon Chikusan Gakkaihō·Yuji Ohashi, Kazunari Ushida
Nov 29, 2014·Pharmaceutical Biology·Yurika YamateKazuya Ooi
Jan 8, 2013·The International Journal of Biochemistry & Cell Biology·J Jasper DeuringC Janneke van der Woude
Apr 15, 2014·Polish Journal of Veterinary Sciences·A ValdovskaM Lazdins
Dec 18, 2015·World Journal of Gastroenterology : WJG·Zhi-Mei XieXiao-Fang Pei
May 23, 2019·Frontiers in Immunology·Felix HaussnerMarkus Huber-Lang

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