Epithelial derived CTGF promotes breast tumor progression via inducing EMT and collagen I fibers deposition

Oncotarget
Xiaoping ZhuStephen Wong

Abstract

Interactions among tumor cells, stromal cells, and extracellular matrix compositions are mediated through cytokines during tumor progression. Our analysis of 132 known cytokines and growth factors in published clinical breast cohorts and our 84 patient-derived xenograft models revealed that the elevated connective tissue growth factor (CTGF) in tumor epithelial cells significantly correlated with poor clinical prognosis and outcomes. CTGF was able to induce tumor cell epithelial-mesenchymal transition (EMT), and promote stroma deposition of collagen I fibers to stimulate tumor growth and metastasis. This process was mediated through CTGF-tumor necrosis factor receptor I (TNFR1)-IκB autocrine signaling. Drug treatments targeting CTGF, TNFR1, and IκB signaling each prohibited the EMT and tumor progression.

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Citations

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Datasets Mentioned

BETA
GSE9691
GSE24202

Methods Mentioned

BETA
xenograft
transfection
Assay
PCR

Software Mentioned

Living Image
SDS
SigmaPlot
ImageExpress
Systat

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