Epithelial downgrowth after Descemet stripping automated endothelial keratoplasty

Cornea
Mark S Gorovoy, Arlene Ratanasit

Abstract

To report the clinical and histological findings of a single patient who developed late epithelial downgrowth of donor origin after Descemet stripping automated endothelial keratoplasty (DSAEK). A 70-year-old woman underwent uneventful DSAEK for Fuchs dystrophy in the right eye. The donor had a thickened graft edge for 2 clock hours laterally. She recovered 20/40 vision by 3 months after operation and was maintained on daily prednisolone acetate drops. Three years postoperatively, a routine examination revealed signs of an asymptomatic epithelial downgrowth exhibited by synechiae and ectropion uvea at the area of the thickened donor edge. Six months later, a faint retrocorneal membrane limited to the donor periphery and contiguous with the thick edge was noted. Visual acuity and intraocular pressure remained unchanged. She was followed for the next 15 months, without intervention until the retrocorneal membrane grew centrally, resulting in graft edema. The iris synechiae remained unchanged. Repeat DSAEK, without iridectomy, was performed with confirmation of epithelial downgrowth of donor origin. Six months postoperatively, the patient has done well without sequela of residual downgrowth. Histopathological evaluation showed epi...Continue Reading

References

Aug 25, 2006·International Ophthalmology Clinics·William W Culbertson
Nov 15, 2006·Cornea·Mark S Gorovoy
Dec 23, 2008·Journal of Cataract and Refractive Surgery·Paul M PhillipsEdwin S Chen

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Citations

Jul 11, 2013·Journal of Ophthalmology·Pavel StudenyPavel Kuchynka
Sep 26, 2014·BioMed Research International·Francesco SemeraroEliana Forbice
Feb 11, 2016·Cornea·Ritika R DalalRobert S Feder
Jun 7, 2013·Journal of Pediatric Ophthalmology and Strabismus·Katja UllrichTheresa Casey
Jun 25, 2015·Case Reports in Ophthalmological Medicine·Nina NiJulia A Haller
Aug 20, 2014·Journal of Cataract and Refractive Surgery·Keunsoo KimTerry Kim
Jan 1, 2013·Journal of Pediatric Ophthalmology and Strabismus·Katja UllrichTheresa Casey

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