Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

Science
Joep GrootjansR S Blumberg

Abstract

Immunoglobulin A (IgA) is the major secretory immunoglobulin isotype found at mucosal surfaces, where it regulates microbial commensalism and excludes luminal factors from contacting intestinal epithelial cells (IECs). IgA is induced by both T cell-dependent and -independent (TI) pathways. However, little is known about TI regulation. We report that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation. IEC ER stress causes TI and microbiota-independent expansion and activation of peritoneal B1b cells, which culminates in increased lamina propria and luminal IgA. Increased numbers of IgA-producing plasma cells were observed in healthy humans with defective autophagy, who are known to exhibit IEC ER stress. Upon ER stress, IECs communicate signals to the peritoneum that induce a barrier-protective TI IgA response.

References

Jul 1, 1986·Journal of Clinical Immunology·L MellanderL A Hanson
Dec 10, 1998·Nucleic Acids Research·M P LefrancD Chaume
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 16, 2003·Science·Hedda WardemannMichel C Nussenzweig
Jul 30, 2004·Genesis : the Journal of Genetics and Development·Fatima el MarjouSylvie Robine
Oct 4, 2005·Proceedings of the National Academy of Sciences of the United States of America·Aravind SubramanianJill P Mesirov
May 17, 2008·Nature Reviews. Immunology·Andrea Cerutti
Dec 2, 2008·Cell Research·Arthur Kaser, Richard S Blumberg
Dec 17, 2008·Mucosal Immunology·A J MacphersonP Brandtzaeg
Jan 30, 2010·Journal of Visualized Experiments : JoVE·Avijit Ray, Bonnie N Dittel
May 7, 2011·Bioinformatics·Arthur LiberzonJill P Mesirov
Oct 30, 2012·Nature Reviews. Immunology·Oliver Pabst
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Oct 4, 2013·Nature·Timon E AdolphRichard S Blumberg
Oct 23, 2013·Journal of Visualized Experiments : JoVE·Paniz KamranReza Ardehali
Feb 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Eric W RogierCharlotte S Kaetzel
Jun 20, 2014·Immunological Reviews·Cindy GutzeitAndrea Cerutti
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
Apr 30, 2015·Nature Methods·Dmitriy A BolotinDmitriy M Chudakov
Nov 26, 2015·PLoS Computational Biology·Mikhail ShugayDmitriy M Chudakov
Jan 16, 2016·Cell Systems·Arthur LiberzonPablo Tamayo
Jun 28, 2016·Nature Reviews. Immunology·Joep GrootjansRichard S Blumberg
Jan 14, 2017·The Journal of Experimental Medicine·Markus TschurtschenthalerArthur Kaser
Mar 2, 2017·The Journal of Clinical Investigation·Claudia Mauri, Madhvi Menon
Apr 6, 2017·Mucosal Immunology·T JoerisA McI Mowat
Oct 4, 2017·Science·Jeffrey J BunkerAlbert Bendelac
May 4, 2018·Science Translational Medicine·Jehane FadlallahGuy Gorochov

❮ Previous
Next ❯

Citations

Oct 12, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuan-Feng ZouZhong-Qiong Yin
Oct 22, 2019·Alcoholism, Clinical and Experimental Research·Hua Wang, Rui Liu
Feb 2, 2020·Nature Reviews. Immunology·Roberta CarusoGabriel Núñez
Jan 4, 2020·Cell Death and Differentiation·Matthew D KellerKen Cadwell
Feb 28, 2020·Nature·Daniel B Graham, Ramnik J Xavier
Feb 11, 2020·Annual Review of Immunology·Shabnam Shalapour, Michael Karin
Apr 17, 2020·JCI Insight·Juan HuangLi Wen
Feb 6, 2020·Nature Reviews. Immunology·Kang ChenAndrea Cerutti
Dec 24, 2019·Frontiers in Immunology·Olivia I Coleman, Dirk Haller
Oct 23, 2019·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Jan 13, 2021·Proceedings of the National Academy of Sciences of the United States of America·Vanessa O EzenwaKaori Sakamoto
Dec 16, 2019·Seminars in Cancer Biology·Monika BhardwajRavi K Amaravadi
Feb 12, 2021·Nature Reviews. Immunology·Kelsey E HuusB Brett Finlay
Jan 26, 2021·Clinical & Translational Immunology·Yu Anne YapEliana Mariño
Feb 9, 2021·Trends in Cell Biology·Siamak Redhai, Michael Boutros
Oct 11, 2020·Signal Transduction and Targeted Therapy·Ziying ZhangYongguang Tao
Apr 4, 2021·International Journal of Molecular Sciences·Bingting YuMaikel P Peppelenbosch
Mar 29, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chen-Chen GaoJing-Dong Xu
Apr 28, 2021·Annual Review of Immunology·Eduard AnsaldoYasmine Belkaid

❮ Previous
Next ❯

Related Concepts

Related Feeds

ATG proteins

The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes.

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms