PMID: 15223860Jun 30, 2004Paper

Epithelial expression and release of FGF-2 from heparan sulphate binding sites in bronchial tissue in asthma

Thorax
J K ShuteP H Howarth

Abstract

The most characteristic structural change evident in endobronchial biopsies in asthma, even in mild disease, is subepithelial collagen deposition within the lamina reticularis. This has been associated with progressive loss of lung function and the persistence of airway hyperresponsiveness, and has been linked to airway fibroblast proliferation. A potent fibroproliferative factor in bronchoalveolar lavage fluid in asthma is fibroblast growth factor-2 (FGF-2). FGF-2 is a member of a family of heparin binding growth factors that bind to heparan sulphate proteoglycans (HSPG), an important determinant of FGF-2 activity. This study compared the level of expression and distribution of FGF-2 in relation to HSPG in bronchial tissue from normal and asthmatic subjects. The distribution of FGF-2 and HSPG in intact and cleaved forms in endobronchial biopsies from normal and asthmatic subjects was examined using an immunohistochemical approach. A novel ELISA based method was developed to detect solubilisation of FGF-2 following addition of heparin and heparitinase to bronchial tissue slices. Immunohistochemical analysis showed that FGF-2 was co-localised to HSPG in epithelial and endothelial basement membranes. Epithelial FGF-2, but not HSP...Continue Reading

References

Oct 1, 1975·The Journal of Allergy and Clinical Immunology·H ChaiR G Townley
Nov 1, 1992·The Journal of Cell Biology·G DavidH Van den Berghe
Apr 1, 1991·The American Review of Respiratory Disease·R DjukanovićP H Howarth
Nov 1, 1990·American Journal of Respiratory Cell and Molecular Biology·C E BrewsterW R Roche
Mar 11, 1989·Lancet·W R RocheS T Holgate
Sep 1, 1993·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·K M BrittenW R Roche
Feb 1, 1997·Endocrine Reviews·A BikfalviD B Rifkin
May 1, 1999·The Journal of Biological Chemistry·T P RichardsonM A Nugent
Jan 29, 2000·The Journal of Cell Biology·A D Lander, S B Selleck
Jun 29, 2000·Annual Review of Biochemistry·M BernfieldM Zako
Feb 15, 2001·The Journal of Allergy and Clinical Immunology·A E RedingtonP H Howarth
Jul 20, 2002·The International Journal of Biochemistry & Cell Biology·Gunilla Westergren-ThorssonGuy M Tremblay

❮ Previous
Next ❯

Citations

Aug 27, 2013·Cell Biochemistry and Biophysics·Vijay K T AlagappanHari S Sharma
Jan 13, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Hiroshi Kanazawa, Junichi Yoshikawa
Dec 14, 2004·Current Opinion in Pulmonary Medicine·Alan James
Oct 26, 2010·American Journal of Respiratory and Critical Care Medicine·Jennifer KearleyAlison A Humbles
Jan 28, 2006·American Journal of Respiratory Cell and Molecular Biology·Ynuk BosséMarek Rola-Pleszczynski
Dec 15, 2012·American Journal of Respiratory Cell and Molecular Biology·Michael SchuligaAlastair G Stewart
Jun 1, 2013·American Journal of Respiratory Cell and Molecular Biology·Michael SchuligaAlastair G Stewart
Aug 23, 2012·Clinical and Translational Allergy·Chrysanthi L SkevakiNikolaos G Papadopoulos
Nov 8, 2006·Molecular Medicine·Geneviève PaulissenDidier D Cataldo
Dec 12, 2012·International Journal of Molecular Sciences·Eirini NeofytouNikolaos M Siafakas
Apr 5, 2007·Cell Biochemistry and Biophysics·Willem I de BoerHari S Sharma
Apr 5, 2014·International Journal of Antimicrobial Agents·Valeria LuciniFrancesco Scaglione
Jan 22, 2008·International Archives of Allergy and Immunology·Ynuk BosséMarek Rola-Pleszczynski
Dec 3, 2014·Pharmacology & Therapeutics·Louise M HarknessJanette K Burgess
Aug 28, 2012·Pulmonary Pharmacology & Therapeutics·David B WrightVarsha Kanabar
Jan 6, 2010·Auris, Nasus, Larynx·Keishin GoKatsuhiro Hirakawa
Dec 7, 2007·Trends in Molecular Medicine·Ynuk Bossé, Marek Rola-Pleszczynski
Aug 18, 2009·British Journal of Pharmacology·Peter Bradding, Heike Wulff
Nov 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Y BosséM Rola-Pleszczynski
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S TourdotC M Lloyd
May 5, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Kostas N PriftisNicolaos M Sitaras
May 27, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Michael J EvansDallas M Hyde
Sep 12, 2015·Journal of Immunology Research·Paul M PeetersNiki L Reynaert
Nov 6, 2013·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Élyse Y BissonnetteCatherine Laprise
Jul 6, 2014·American Journal of Respiratory Cell and Molecular Biology·Robert D GuzyDavid M Ornitz
May 18, 2016·Life Sciences·Luiz André C BrizenoMário Rogério L Mota
Sep 27, 2016·Pulmonary Pharmacology & Therapeutics·Jatinder SinghDhandeep Singh
Oct 27, 2016·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elie El AghaSaverio Bellusci
Jan 4, 2017·PloS One·Akul SinghaniaPeter H Howarth
Oct 26, 2018·The Journal of Pathology·Soula DanopoulosDenise Al Alam
Apr 18, 2020·Frontiers in Cell and Developmental Biology·Yuanyang TanYan Yan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.