Epithelial-Mesenchymal Transition: A Major Pathogenic Driver in Idiopathic Pulmonary Fibrosis?

Medicina
Francesco SaltonMarco Confalonieri

Abstract

Despite the fact that epithelial-mesenchymal transition (EMT) is a common downstream mechanism of all fibrosing diseases, whether it represents a leading process in the development of idiopathic pulmonary fibrosis has been widely discussed and is still a matter of debate. According to the most recent advances, EMT is thought to be mainly driven by the overexpression of several developmental pathways upstream of dysfunctional epithelial regeneration, which indeed normally occurs after damage and during tissue turnover. Future research should likely be directed at investigating the molecular mechanisms underlying epithelial dysfunction, in order to allow for both the removal of the wording "idiopathic" from idiopathic pulmonary fibrosis ("IPF") and for the identification of earlier and more effective therapeutic targets than the late process of fibrosis.

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Citations

Jan 6, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Michael J Abramson, E Haydn Walters
Mar 31, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mudassir M BandayNirmal S Sharma
Apr 4, 2021·International Journal of Molecular Sciences·Barbara RuaroMarco Confalonieri
Jul 3, 2021·Journal of Clinical Medicine·Barbara RuaroFrancesco Salton
Nov 5, 2021·Frontiers in Medicine·Hee-Young YoonJin Woo Song

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