Epithelial-Mesenchymal Transition (EMT) and Regulation of EMT Factors by Steroid Nuclear Receptors in Breast Cancer: A Review and in Silico Investigation

Journal of Clinical Medicine
Ioannis A Voutsadakis

Abstract

Steroid Nuclear Receptors (SNRs) are transcription factors of the nuclear receptor super-family. Estrogen Receptor (ERα) is the best-studied and has a seminal role in the clinic both as a prognostic marker but also as a predictor of response to anti-estrogenic therapies. Progesterone Receptor (PR) is also used in the clinic but with a more debatable prognostic role and the role of the four other SNRs, ERβ, Androgen Receptor (AR), Glucocorticoid Receptor (GR) and Mineralocorticoid Receptor (MR), is starting only to be appreciated. ERα, but also to a certain degree the other SNRs, have been reported to be involved in virtually every cancer-enabling process, both promoting and impeding carcinogenesis. Epithelial-Mesenchymal Transition (EMT) and the reverse Mesenchymal Epithelial Transition (MET) are such carcinogenesis-enabling processes with important roles in invasion and metastasis initiation but also establishment of tumor in the metastatic site. EMT is governed by several signal transduction pathways culminating in core transcription factors of the process, such as Snail, Slug, ZEB1 and ZEB2, and Twist, among others. This paper will discuss direct regulation of these core transcription factors by SNRs in breast cancer. Interr...Continue Reading

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Citations

Sep 4, 2016·Pathology Oncology Research : POR·Golnoush Dehbashi BehbahaniSadegh Babashah
Mar 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ioannis A Voutsadakis
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Mar 30, 2019·Journal of Experimental & Clinical Cancer Research : CR·Zizhuo LiXiuhua Yang
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Dec 2, 2020·Molecular Biology Reports·Ioannis A Voutsadakis
Feb 15, 2018·Molecular Cancer Therapeutics·Nagore I Marín-RamosFlorence M Hofman
Feb 12, 2021·International Journal of Molecular Sciences·Janusz BlasiakKai Kaarniranta
Mar 7, 2021·Journal of Clinical Medicine·Paul MozarowskiIoannis A Voutsadakis

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Methods Mentioned

BETA
hormone replacement therapy
transfection
ChIP-seq
GTPase
transgenic

Software Mentioned

Transcriptomine

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