Epithelial Mesenchymal Transition (EMT) in Metastatic Breast Cancer in Omani Women

Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society
Ritu LakhtakiaShyam S Ganguly

Abstract

Breast cancer (BC) in Oman affects younger women and has a more aggressive course. Clinical and biological variables like age, pregnancy, tumor size, type, grade, receptor expression and proliferation predict disease aggression but there is no direct predictor of metastasis except lymphovascular invasion. Epithelial-mesenchymal transition (EMT) is characterized by epithelial cells losing epithelial and acquiring mesenchymal morpho-immunophenotypic characteristics. In tumors, EMT-like transitions may signify a metastatic phenotype and have features in common with cancer stem cells (CSC) which show resistance to chemotherapy. This study aimed to identify EMT and CSC phenotypes in metastatic and non-metastatic breast cancer in Omani women and their association with conventional clinico-pathological predictors of BC. In a retrospective study of ninety-six Omani women with breast cancer, the association of age, pregnancy/lactation, tumor size, type, grade, ductal carcinoma insitu (DCIS), lymphovascular invasion, hormone/ HER2 receptor expression and Ki67 proliferation index (Ki67 PI) was tested with EMT/ CSC phenotype and metastasis. Young age ≤ 40 years, lymphovascular invasion and EMT had a strong association with metastasis; CSC ...Continue Reading

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Citations

Jul 3, 2019·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Zhuocheng YaoFei Zou
Nov 6, 2018·Molecular Medicine Reports·Zhouhui RenPing Wang
Jul 31, 2019·Cellular Signalling·Spyros S SkandalisNikos K Karamanos
Apr 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tiantian QinCong Wang

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Methods Mentioned

BETA
biopsies
biopsy
flow cytometry

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