Epithelial mesenchymal transition is a characteristic of hyperplasias and tumors in mammary gland from MMTV-Cripto-1 transgenic mice

Journal of Cellular Physiology
Luigi StrizziDavid S Salomon

Abstract

Epithelial-mesenchymal transition (EMT) facilitates migration and invasion of epithelial tumor cells. Cripto-1 (CR-1), a member of the epidermal growth factor-CFC protein family increases migration of cells in vitro. Here the expression of molecular markers and signaling molecules characteristic of EMT were assessed in mammary gland hyperplasias and tumors from mice expressing the human CR-1 transgene by the MMTV promoter (MMTV-CR-1) and in mouse mammary epithelial cell line HC-11 overexpressing CR-1 (HC-11/CR-1). Western blot analysis showed decreased expression of E-cadherin in MMTV-CR-1 tumors and in HC-11/CR-1 cells. The expression of N-cadherin, vimentin, cyclin-D1, and of the zinc-finger transcription factor, snail, was increased in MMTV-CR-1 tumors. Increased snail mRNA was also found in HC-11/CR-1 cells. Expression of phosphorylated (P)-c-Src, P-focal adhesion kinase (FAK), P-Akt, P-glycogen synthease kinase 3beta (GSK-3beta), dephosphorylated (DP)-beta-catenin, and various integrins such as, alpha 3, alpha v, beta 1, beta 3, and beta 4 was also increased in MMTV-CR-1 tumors. Immunohistochemistry showed positive staining for vimentin, N-cadherin, cyclin-D1, smooth muscle actin, fibronectin, snail, and beta-catenin in MM...Continue Reading

References

Oct 1, 1992·Current Opinion in Cell Biology·S TsukitaS Yonemura
Jan 1, 1988·Annual Review of Biochemistry·P M Steinert, D R Roop
Jul 1, 1995·Clinical & Experimental Metastasis·M MaemuraR B Dickson
Jan 1, 1994·Annual Review of Biochemistry·E Fuchs, K Weber
Jan 1, 1996·Acta Anatomica·C BirchmeierB Brand-Saberi
Jan 1, 1997·Critical Reviews in Biochemistry and Molecular Biology·J T PriceE C Kohn
Aug 12, 1998·The Journal of Cell Biology·N A Chitaev, S M Troyanovsky
Oct 3, 1999·Cancer Metastasis Reviews·J P Thiery, D Chopin
Feb 25, 2000·The International Journal of Biochemistry & Cell Biology·M G Coppolino, S Dedhar
Aug 26, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R J JonesM C Frame
Sep 29, 2000·Biochemical Pharmacology·B BoyerN Edme
May 8, 2001·Experimental Cell Research·C WechselbergerD S Salomon
Sep 27, 2001·Journal of Cellular Physiology·E H Danen, K M Yamada
Oct 10, 2001·Current Biology : CB·C J Gottardi, B M Gumbiner
Oct 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P Savagner
Mar 23, 2002·Molecular and Cellular Biology·Caterina BiancoDavid S Salomon
May 7, 2002·Gene·Gabriella MinchiottiM Graziella Persico
May 8, 2002·Nature Reviews. Molecular Cell Biology·M Angela Nieto
Sep 12, 2002·EMBO Reports·Beric R Henderson, Francois Fagotto
Sep 18, 2002·European Journal of Cell Biology·Jae Youn YiYoung Sook Son
Sep 27, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Petra PandurMichael Kühl
Oct 3, 2002·Journal of Cell Science·Joerg Huelsken, Juergen Behrens
Oct 17, 2002·The Anatomical Record·José M Pérez-Pomares, Ramón Muñoz-Chápuli
Dec 31, 2002·American Journal of Physiology. Renal Physiology·Andras MassziAndrás Kapus
Feb 26, 2003·The Journal of Biological Chemistry·Tianyun Jiang, Yun Qiu
May 17, 2003·Experimental Cell Research·DeannaLee M Beauvais, Alan C Rapraeger
Jul 8, 2003·The Journal of Pathology·Erik H J Danen, Arnoud Sonnenberg

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Citations

Jan 27, 2009·Cancer Metastasis Reviews·Jihe Zhao, Jun-Lin Guan
Apr 7, 2010·Journal of Mammary Gland Biology and Neoplasia·Katharine M HardyLuigi Strizzi
May 22, 2010·Journal of Mammary Gland Biology and Neoplasia·Douglas S MicalizziHeide L Ford
Jun 4, 2010·Journal of Mammary Gland Biology and Neoplasia·Robert Darrell Cardiff
Mar 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Lynne-Marie PostovitMary J C Hendrix
Jan 20, 2005·Journal of the National Cancer Institute·Caterina BiancoDavid S Salomon
Dec 1, 2009·Journal of Angiogenesis Research·Kafi N MeadowsLaura E Benjamin
Oct 27, 2009·Future Oncology·Enrico RadaelliRobert D Cardiff
Jul 14, 2010·Future Oncology·Nadia Pereira de CastroCaterina Bianco
Aug 30, 2008·International Journal of Biological Sciences·Yan-gao Man, William A Gardner
Apr 4, 2009·International Journal of Biological Sciences·Aijun LiuYan-Gao Man
May 9, 2014·International Journal of Oncology·Emilia GiorgioGiovanna L Liguori
Jun 10, 2014·The Journal of Clinical Investigation·Kang-Seo ParkGiuseppe Giaccone
Sep 25, 2014·Science Signaling·David M Gonzalez, Damian Medici
Aug 27, 2005·Oncogene·Luigi StrizziDavid Salomon
Nov 16, 2010·Expert Opinion on Therapeutic Patents·Caterina Bianco, David S Salomon
Sep 4, 2015·Connective Tissue Research·Malgorzata KlauzinskaFrank Cuttitta
May 17, 2015·FEBS Letters·Ruben Bill, Gerhard Christofori
Jun 7, 2011·Gene·V RavisankarNarayanan Manoj
Oct 17, 2009·The American Journal of Pathology·Caterina BiancoDavid S Salomon
Jan 19, 2008·The American Journal of Pathology·Caterina BiancoDavid S Salomon
Feb 13, 2007·Biochemical and Biophysical Research Communications·Shin HamadaDavid S Salomon
Mar 13, 2016·Breast Cancer Research and Treatment·Maria Cristina RangelDavid S Salomon
Oct 18, 2007·Journal of Cellular Physiology·Mario MancinoCaterina Bianco
Apr 22, 2008·Journal of Cellular Physiology·Luigi StrizziDavid S Salomon
Jul 10, 2010·The American Journal of Pathology·Caterina BiancoDavid S Salomon
Mar 31, 2016·Cell Cycle·Eric D Young, Danny R Welch
Sep 28, 2005·Trends in Biochemical Sciences·Kellye C KirkbrideGerard C Blobe
Sep 3, 2005·Experimental Cell Research·Christian WechselbergerDavid S Salomon

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