Epithelial-mesenchymal transition polarization in ovarian carcinomas from patients with high social isolation.

Cancer
Susan K LutgendorfSteve W Cole

Abstract

Social isolation has shown robust associations with clinical outcomes in the general population and in patients with cancer. In patients with ovarian cancer, social isolation has been found to be related to decreased survival and multiple biomarkers supporting tumor progression. However, to the authors' knowledge, little is known regarding the relationship between social isolation and the molecular characteristics of ovarian tumors. Herein, the authors have used genome-wide transcriptional profiling to quantify associations between social isolation and epithelial-mesenchymal transition (EMT) polarization in ovarian tumors and transcriptome-driven, promoter-based bioinformatics analyses to identify gene regulatory pathways that may potentially underlie these changes. Tumor was sampled during primary surgical resection and immediately frozen in liquid nitrogen. After RNA extraction, microarray analysis of the transcriptome was performed and samples were analyzed to assess associations between EMT-related gene transcripts and social isolation (as indicated by a Social Provisions Scale Attachment subscale score <15). Convergent validation was provided by a promoter-based bioinformatic analysis of transcription factor activity. Prim...Continue Reading

References

Sep 18, 2004·Bioinformatics·Steve W ColeJerome A Zack
Jun 15, 2005·Cancer·Erin S CostanzoDavid M Lubaroff
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan K LutgendorfDavid M Lubaroff
Jun 14, 2008·Brain, Behavior, and Immunity·Susan K LutgendorfSteve W Cole
Aug 14, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard W TothillDavid D L Bowtell
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susan K LutgendorfAnil K Sood
Jan 21, 2009·Cell Research·Jian XuRik Derynck
Jul 17, 2009·Critical Reviews in Oncology/hematology·Martin Pinquart, Paul R Duberstein
Oct 20, 2010·Brain, Behavior, and Immunity·Susan K LutgendorfSteve W Cole
Jul 18, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan K LutgendorfAnil K Sood
Dec 20, 2014·Cancer Research·Maria V BogachekRonald J Weigel
Aug 25, 2015·Nature Reviews. Cancer·Steven W ColeAnil K Sood
Jan 6, 2016·Proceedings of the National Academy of Sciences of the United States of America·Yang Claire YangKathleen Mullan Harris
Mar 2, 2016·Nature Communications·Caroline P LeErica K Sloan
May 27, 2016·Breast Cancer Research : BCR·Adam HinzeyA Courtney DeVries
Jul 28, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Bowen Du, Joong Sup Shim
May 12, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lee ShaashuaShamgar Ben-Eliyahu
Nov 8, 2017·Cancer·Susan K LutgendorfSteve W Cole
Feb 8, 2018·Annual Review of Pathology·Vivek Mittal
Feb 25, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Courtney E BoenYang Claire Yang
Apr 20, 2018·Nature·Ievgenia PastushenkoCédric Blanpain
Jul 31, 2018·JNCI Cancer Spectrum·Julienne E BowerSteve W Cole
Oct 17, 2018·American Journal of Epidemiology·Kassandra I AlcarazSusan M Gapstur
Mar 15, 2019·Nature·Milan M S ObradovićMohamed Bentires-Alj
Mar 27, 2019·Proceedings of the National Academy of Sciences of the United States of America·Cornelia KrögerRobert A Weinberg
Apr 5, 2019·Cancer Discovery·Sam FaulknerHubert Hondermarck
Nov 23, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan G HillerErica K Sloan
Dec 17, 2019·Gynecologic Oncology·Lauren C PeresShelley S Tworoger

❮ Previous
Next ❯

Citations

Jun 4, 2021·Psychosomatic Medicine·Michaela G CuneoSusan K Lutgendorf
Sep 12, 2021·Nature Reviews. Cancer·Anabel EckerlingShamgar Ben-Eliyahu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.