Epithelial-mesenchymal transitions in development and disease

Cell
Jean Paul ThieryM Angela Nieto

Abstract

The epithelial to mesenchymal transition (EMT) plays crucial roles in the formation of the body plan and in the differentiation of multiple tissues and organs. EMT also contributes to tissue repair, but it can adversely cause organ fibrosis and promote carcinoma progression through a variety of mechanisms. EMT endows cells with migratory and invasive properties, induces stem cell properties, prevents apoptosis and senescence, and contributes to immunosuppression. Thus, the mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.

References

Aug 30, 2001·Proceedings of the National Academy of Sciences of the United States of America·T BrabletzT Kirchner
Nov 2, 2001·Molecular and Cellular Biology·E A CarverT Gridley
Jul 19, 2002·Clinical Genetics·K A Johansson, Anne Grapin-Botton
Jan 31, 2003·The New England Journal of Medicine·María Yáñez-MóManuel López-Cabrera
Feb 18, 2003·Journal of Anatomy·Margaret BuckinghamFrédéric Relaix
Aug 14, 2003·American Journal of Physiology. Renal Physiology·Michael ZeisbergRaghu Kalluri
Dec 31, 2003·Developmental Biology·Concepción Martínez-AlvarezM Angela Nieto
Jan 1, 2004·Genes & Development·Luika A TimmermanJosé Luis de la Pompa
Jan 23, 2004·Nature Reviews. Cancer·John Condeelis, Jeffrey E Segall
May 25, 2004·Genes & Development·Sonia VegaM Angela Nieto
Jul 20, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Shizuya SaikaAnita B Roberts
Aug 18, 2004·Molecular and Cellular Biology·Masahiro KajitaPaul A Wade
Apr 22, 2005·Nature·Jérôme GrosChristophe Marcelle
Apr 29, 2005·Development·Jaime De CalistoRoberto Mayor
May 21, 2005·The International Journal of Developmental Biology·Anne-Hélène Monsoro-Burq
Jun 29, 2005·Development·Alejandro Barrallo-Gimeno, M Angela Nieto
Jul 27, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roy S HerbstUNKNOWN TRIBUTE Investigator Group
Aug 2, 2005·Seminars in Cell & Developmental Biology·Robert A Cornell, Judith S Eisen
Sep 9, 2005·Nature Reviews. Cancer·Thomas BrabletzThomas Kirchner
Sep 20, 2005·Cancer Cell·Susan E MoodyLewis A Chodosh
Nov 25, 2005·British Journal of Cancer·A PuisieuxS Ansieau
Dec 20, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert L YauchLukas C Amler
Jan 6, 2006·American Journal of Physiology. Cell Physiology·Nuzhat AhmedNelly Auersperg
Feb 24, 2006·Nature Reviews. Molecular Cell Biology·Jean Paul Thiery, Jonathan P Sleeman

❮ Previous
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Citations

May 30, 2013·Cellular and Molecular Life Sciences : CMLS·Luis A AparicioAngélica Figueroa
Sep 11, 2012·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hui-Chen PaiShiow-Lin Pan
Mar 22, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Heath A Smith, Yibin Kang
Sep 26, 2012·Archives of Toxicology·Rajagopal N AravalliClifford J Steer
Jun 7, 2012·Histochemistry and Cell Biology·Stefanie Krück, Martin Scaal
Feb 22, 2012·Langenbeck's Archives of Surgery·Gunnar SteinertJürgen Weitz
Jun 7, 2011·Cell and Tissue Research·Carl-Henrik Heldin, Aristidis Moustakas
Jun 22, 2011·Cell and Tissue Research·Michael K WendtWilliam P Schiemann
Feb 12, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Ivica GrgicBenjamin D Humphreys
Jul 10, 2013·Amino Acids·Zhiyuan Ma, Keith Vosseller
Mar 30, 2013·Breast Cancer Research and Treatment·Heather M MooreCelina G Kleer
Oct 6, 2010·Cancer Metastasis Reviews·Carlos A CastanedaEva M Ciruelos
Oct 13, 2010·Cancer Metastasis Reviews·Ming ShiNing Guo
Nov 22, 2011·Cancer Metastasis Reviews·Paolo Cirri, Paola Chiarugi
Mar 1, 2012·Cancer Metastasis Reviews·Rajeshwari R ValiathanRafael Fridman
Jun 14, 2012·Cancer Metastasis Reviews·Sung-Gook ChoMingyao Liu
Jun 27, 2012·Cancer Metastasis Reviews·Natalia Bednarz-KnollKlaus Pantel
Jun 16, 2012·Cancer Metastasis Reviews·Jonathan P Sleeman
Jun 26, 2012·Cancer Metastasis Reviews·N P A Devika GunasingheHonor J Hugo
Apr 30, 2013·Cancer Metastasis Reviews·David Tarin
Aug 3, 2013·Cancer Metastasis Reviews·Jeff M P HollyClaire M Perks
Apr 17, 2010·Cell Biology and Toxicology·Modjtaba Emadi BaygiWolfgang A Schulz
Jan 5, 2011·Clinical & Experimental Metastasis·Stuart ThomsonJohn D Haley
Jun 7, 2011·Clinical & Experimental Metastasis·Gretchen M ArgastDavid M Epstein
Jul 27, 2011·Clinical & Experimental Metastasis·Sylvie Dubois-MarshallElad Katz
Sep 1, 2011·Clinical & Experimental Metastasis·Kyoko Kushiro, Nomelí P Núñez
Jul 17, 2012·Clinical & Experimental Metastasis·Marlys H WitteFrancesco Boccardo
Oct 12, 2012·Clinical & Experimental Metastasis·Harold J WaneboNancey E Kemeny
Jun 4, 2013·Clinical & Experimental Metastasis·Susan SpechtAnthony J Demetris
Apr 7, 2010·Journal of Mammary Gland Biology and Neoplasia·Katharine M HardyLuigi Strizzi
May 8, 2010·Journal of Mammary Gland Biology and Neoplasia·Arnaud BonnometChristine Gilles
May 5, 2010·Journal of Mammary Gland Biology and Neoplasia·Evette S Radisky, Derek C Radisky
May 13, 2010·Journal of Mammary Gland Biology and Neoplasia·Nathan J GoddePatrick O Humbert

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