Epithelial proliferation and ras p21 oncoprotein expression in rectal mucosa of patients with ulcerative colitis

Digestive Diseases and Sciences
E IerardiA Francavilla

Abstract

In ulcerative colitis (UC), epithelial proliferation plays a role in crypt repair and neoplastic evolution. Proliferative status is predominantly connoted in active disease, but not defined in remission. Histologically, remission is characterized by normalization of the picture or development of atrophy. Mutation of the ras oncogene is involved in intestinal carcinogenesis. Aim of this work was to assess the proliferative pattern of rectal epithelium in UC during disease activity and in remission and correlate it with ras oncoprotein p21. The study was performed retrospectively in rectal biopsies from four groups each of 10 patients: active ulcerative colitis (AUC), remission with a normal histology (RUC), remission with rectal atrophy (ARUC), and irritable bowel syndrome (C, control group). In all, immunohistostain was employed to evaluate the proliferation cell nuclear antigen labeling index (PCNA LI) and ras p21. Statistical analysis was performed by ANOVA and Student-Neumann-Keuls tests. PCNA LI was significantly higher in AUC and ARUC than in RUC and C. Positive cells were predominant in the lower zone of crypts in RUC and C, while a significant expression of PCNA was also observed in the upper areas in AUC and ARUC. Oncop...Continue Reading

Citations

Oct 16, 2008·Science Progress·Ratchada PattaranitDavid Spanswick
Jun 19, 2010·Helicobacter·Cesare HassanEnzo Ierardi
Sep 11, 2014·World Journal of Gastroenterology : WJG·Mariabeatrice PrincipiAlfredo Di Leo
May 10, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Bart Deplancke, H Rex Gaskins
Jul 3, 2010·Expert Review of Clinical Immunology·Thomas T MacDonald
Apr 12, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·José Eduardo de Aguilar-Nascimento
Jun 4, 2005·Alimentary Pharmacology & Therapeutics·S MoriniE Ierardi
Mar 21, 2015·Inflammatory Bowel Diseases·Elena TaleroVirginia Motilva
Feb 1, 2006·Molecular Cancer Research : MCR·Matias S Attene-RamosH Rex Gaskins

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