Epithelial proliferation in explants of mouse palatal mucosa cultured in contact and apart

Virchows Archiv. B, Cell Pathology Including Molecular Pathology
D A Luke

Abstract

Explants of mouse palatal mucosa were cultured on grids either in isolation or with their lateral margins in contact. After 25 h the labelling index (LI) was determined using 3HTdR. At the edge of explants in contact LI was 59% that of explants cultured apart but the mean grain count was similar in the two groups. Metaphase arrest using vinblastine between 24--28 h of culture showed that in the basal cells, the rate of entry into mitosis was 1.1% per hour in explants cultured in contact and 1.9% per hour in explants cultured apart. In both groups the duration of mitosis was 1.0 h. Since in vivo the rate of entry into mitosis in this tissue is 1.2% per hour, the result suggest that an increase in epithelial proliferation does occur near to the edge of cultured mucosal explants and that this is diminished by the proximity of the edge of a second explant.

References

Oct 1, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·I L HansteenS B Refsum
Feb 6, 1979·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·D A Luke
Dec 1, 1978·Archives of Dermatological Research·P R Gradwohl
Jan 1, 1959·Experimental Cell Research·O A TROWELL
Mar 1, 1960·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·W S BULLOUGH, E B LAURENCE
Aug 1, 1962·Biological Reviews of the Cambridge Philosophical Society·W S BULLOUGH
Jun 1, 1963·Experimental Cell Research·E A HELL, C N CRUICKSHANK

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Citations

Dec 1, 1983·Journal of Oral Pathology·I C Mackenzie, W H Binnie

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