Epithelial to mesenchymal transition: new and old insights from the classical neural crest model.

Seminars in Cancer Biology
Pablo H Strobl-Mazzulla, Marianne E Bronner

Abstract

The epithelial-to-mesenchymal transition (EMT) is an important event converting compact and ordered epithelial cells into migratory mesenchymal cells. Given the molecular and cellular similarities between pathological and developmental EMTs, studying this event during neural crest development offers and excellent in vivo model for understanding the mechanisms underlying this process. Here, we review new and old insight into neural crest EMT in search of commonalities with cancer progression that might aid in the design of specific therapeutic prevention.

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Citations

Oct 3, 2012·PloS One·G Wayne Brodland, Jim H Veldhuis
Sep 19, 2012·The Journal of Cell Biology·Pablo H Strobl-Mazzulla, Marianne E Bronner
Nov 12, 2014·Annual Review of Medicine·Chrystal U Louis, Jason M Shohet
Dec 3, 2014·Proceedings of the National Academy of Sciences of the United States of America·Na HuMarianne E Bronner
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May 12, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Haley DunkelFrances Lefcort
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Jul 19, 2016·Journal of Cellular Biochemistry·Peter E ZageJason M Shohet
Jun 24, 2019·Cell Communication and Signaling : CCS·Deepak KumarChaya Kalcheim

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